The Contribution of Angiogenesis to the Process of Metastasis.
The Contribution of Angiogenesis to the Process of Metastasis.
复制标题
血管生成对转移过程的贡献。
DOI：
10.1097/ppo.0000000000000138
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发表时间：
2015-07
期刊：
影响因子：
--
通讯作者：
Zetter BR
中科院分区：
文献类型：
--
作者：
Bielenberg DR;Zetter BR
血管生成在肿瘤生长中的作用已经持续研究了超过45年。现在认识到，血管生成对于肿瘤转移的扩散和建立也是必不可少的。在这篇综述中，我们着重于血管生成作为肿瘤细胞逃逸到血液中以及在次级部位建立转移集落所必需的作用。我们还讨论了肿瘤淋巴管生成作为淋巴转移扩散途径的作用。通过合理使用抗血管生成疗法和抗淋巴管生成疗法，未来可能会使用适当的联合疗法来预防和治疗转移性疾病，方法是根据该领域当前和未来的工作情况。
The role of angiogenesis in tumor growth has been studied continuously for over 45 years. It is now appreciated that angiogenesis is also essential for the dissemination and establishment of tumor metastases. In this review, we focus on the role of angiogenesis as a necessity for the escape of tumor cells into the bloodstream and for the establishment of metastatic colonies in secondary sites. We also discuss the role of tumor lymphangiogenesis as a means of dissemination of lymphatic metastases. Appropriate combination therapies may be used in the future to both prevent and treat metastatic disease through the rational use of anti-angiogenic and anti-lymphangiogenic therapies in ways that are informed by the current and future work in the field.