The effects of chronic corticosterone on hippocampal astrocyte numbers: a comparison of male and female Wistar rats.

The effects of chronic corticosterone on hippocampal astrocyte numbers: a comparison of male and female Wistar rats.
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慢性皮质酮对海马星形胶质细胞数量的影响：雄性和雌性 Wistar 大鼠的比较。

DOI：
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发表时间：
2008
期刊：
Acta Neurobiologiae Experimentalis
影响因子：
1.4
通讯作者：
E. Sykova
E. Sykova
中科院分区：
医学4区
文献类型：
--
作者：
N. Bridges;K. Šlais;E. Sykova

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慢性应激和/或糖皮质激素给药导致海马神经元萎缩。然而，糖皮质激素对神经胶质细胞（尤其是男性和女性）影响的证据有限。在本研究中，我们调查了总的百分比体重，海马体积和海马星形胶质细胞数量慢性皮质酮治疗后，雄性和雌性Wistar大鼠。男性的左右海马体积总体上更大，但皮质酮治疗后对海马体积没有影响。两种性别大鼠的总体重均呈剂量依赖性降低，但雄性大鼠的降低更为显著。皮质酮处理剂量依赖性地增加CA 1区的星形胶质细胞数量，但在外侧和内侧CA 3海马区没有。雄性和雌性大鼠的这种增加相似。慢性皮质酮后观察到的星形胶质细胞增生可能对突触外通讯和神经元-胶质细胞相互作用有影响，并且与在老年大鼠中观察到的星形胶质细胞群体的变化相似。
Chronic stress an/or glucocorticoid administration produces atrophy of hippocampal neurons. However, evidence of the impact of glucocorticoids on glial cells, especially in both males and females, is limited. In the present study, we investigated the total percentage body weight, hippocampal volume and hippocampal astrocyte numbers following chronic corticosterone treatment in male and female Wistar rats. Males had greater left and right hippocampal volumes overall, but no effect on hippocampal volume was seen after corticosterone treatment. Total body weight was dose-dependently lower in both sexes, but the decrease was more prominent in male rats. Corticosterone treatment dose-dependently increased astrocyte numbers in the CA1 region, but not in the lateral and medial CA3 hippocampal regions. This increase was similar in both male and female rats. The astrogliosis observed following chronic corticosterone may have implications for extrasynaptic communication and neuron-glia interactions and is similar to changes in the astrocytic population observed in aged rats.
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DOI： --
发表时间： --
期刊： --
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作者：
Lisa Blockinshin;Stephan Blockinheckers;Scott Blockinp Blockinorr;Daniel Blockinl Blockinschacter;Blockinstephan Blockinheckers;Lisa M. Shin;Patrick S Shin;S. Heckers;Terri S Krangel;M. L. Macklin;S. Orr;N. Lasko;E. Segal;J. Levering;D. Schacter;Nathaniel M. Alpert;A J. Fischman;R. Pitman;Scott L. Rauch
通讯作者： Lisa Blockinshin;Stephan Blockinheckers;Scott Blockinp Blockinorr;Daniel Blockinl Blockinschacter;Blockinstephan Blockinheckers;Lisa M. Shin;Patrick S Shin;S. Heckers;Terri S Krangel;M. L. Macklin;S. Orr;N. Lasko;E. Segal;J. Levering;D. Schacter;Nathaniel M. Alpert;A J. Fischman;R. Pitman;Scott L. Rauch