CERVICOVAGINAL HUMAN PAPILLOMAVIRUS INFECTION IN SUBURBAN ADOLESCENTS AND YOUNG-ADULTS
CERVICOVAGINAL HUMAN PAPILLOMAVIRUS INFECTION IN SUBURBAN ADOLESCENTS AND YOUNG-ADULTS
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DOI：
10.1016/s0022-3476(05)80311-7
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发表时间：
1991-11-01
影响因子：
5.1
通讯作者：
BURK, RD
中科院分区：
文献类型：
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作者：
FISHER, M;ROSENFELD, WD;BURK, RD
为了调查白人中产阶级青少年生殖器人类乳头瘤病毒(HPV)感染的患病率和危险因素，我们从107名在郊区青少年健康服务机构接受盆腔检查的患者中获得了HPV样本。宫颈阴道灌洗取标本，用Southern印迹法检测HPVDNA。受试者的平均年龄为18.5(+/-2.0 SD)岁；47%的受试者接受避孕治疗，36%的受试者可能怀孕，12%的受试者患有妇科疾病，5%的受试者接受一般检查。我们在32%的患者中检测到HPV；HPV类型包括6/11(6%)、16(3%)、18(15%)、34(3%)、42(6%)、45(18%)和56(6%)。47%的人将DNA类型归类为无特征性，3%的人有一种以上类型。单因素分析显示，发现HPV的患者有两个以上的性伴、性生活2年以上、12岁以前有月经初潮、有性传播疾病病史；Logistic回归多因素分析显示伴数和初潮年龄是HPV的独立危险因素。这些数据表明，HPV在性活跃的青少年中很常见，无论其种族或社会经济地位如何。宫颈阴道HPV感染与性行为的关联进一步支持了这种病原体的性传播的概念。
To investigate the prevalence rates of and risk factors for genital human papillomavirus (HPV) infection in white, middle-class adolescents, we obtained specimens for HPV from 107 patients undergoing pelvic examination at a suburban adolescent health service. Specimens were obtained by means of cervicovaginal lavage and were analyzed for HPV DNA by Southern blot analysis. The subjects' mean age was 18.5 (+/- 2.0 SD) years; 47% of the subjects were seen for contraception, 36% for possible pregnancy, 12% for a gynecologic complaint, and 5% for a general examination. We detected HPV in 32% of patients; HPV types included 6/11 (6%), 16 (3%), 18 (15%), 34 (3%), 42 (6%), 45 (18%), and 56 (6%). The DNA type was classified as uncharacterized in 47%, and 3% had more than one type. Univariate analysis revealed that patients found to have HPV were more likely to have more than two sexual partners, to have been sexually active for more than 2 years, to have had menarche before 12 years of age, and to have a history of sexually transmitted disease; logistic regression multivariate analysis demonstrated that number of partners and age at menarche were independent risk factors for HPV. These data indicate that HPV is common among sexually active teenagers regardless of ethnicity or socioeconomic status. The association of cervicovaginal HPV infection with sexual activity further supports the notion of the sexual transmission of this agent.