Dynamics and complexity of body temperature in preterm infants nursed in incubators.
Dynamics and complexity of body temperature in preterm infants nursed in incubators.
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DOI：
10.1371/journal.pone.0176670
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Schulzke SM
中科院分区：
文献类型：
--
作者：
Jost K;Pramana I;Delgado-Eckert E;Kumar N;Datta AN;Frey U;Schulzke SM
体温控制不良与早产儿的死亡率和主要发病率相关。我们的目的是量化其动态和复杂性，以评估在出生后前5天内获得的温度时间序列波动分析的指标是否与胎龄（GA）和出生时的体型以及早产典型合并症的存在和严重程度相关。我们记录了3小时的体温时间序列使用皮肤电极在恒温箱护理早产儿。我们计算的平均值和变异系数的体温，标度指数α（Talpha）来自去趋势波动分析，和样本熵（TSampEn）的温度波动。资料采用多水平多元线性回归分析。从73/90例婴儿（81%）的285/357次测量（80%）中获得了技术质量满意的数据，平均（范围）GA为30.1（24.0-34.0）周。我们发现，在调整GA和出生体重z评分后，T α与呼吸支持水平的增加呈正相关（p<0.001; R2 = 0.38）。动态和复杂的体温在保温箱护理的早产儿显示出相当大的关联与GA和呼吸道疾病的发病率。Talpha可能是早产儿自主神经成熟度和疾病严重程度的一个有用标志。
Poor control of body temperature is associated with mortality and major morbidity in preterm infants. We aimed to quantify its dynamics and complexity to evaluate whether indices from fluctuation analyses of temperature time series obtained within the first five days of life are associated with gestational age (GA) and body size at birth, and presence and severity of typical comorbidities of preterm birth. We recorded 3h-time series of body temperature using a skin electrode in incubator-nursed preterm infants. We calculated mean and coefficient of variation of body temperature, scaling exponent alpha (Talpha) derived from detrended fluctuation analysis, and sample entropy (TSampEn) of temperature fluctuations. Data were analysed by multilevel multivariable linear regression. Data of satisfactory technical quality were obtained from 285/357 measurements (80%) in 73/90 infants (81%) with a mean (range) GA of 30.1 (24.0–34.0) weeks. We found a positive association of Talpha with increasing levels of respiratory support after adjusting for GA and birth weight z-score (p<0.001; R2 = 0.38). Dynamics and complexity of body temperature in incubator-nursed preterm infants show considerable associations with GA and respiratory morbidity. Talpha may be a useful marker of autonomic maturity and severity of disease in preterm infants.