Virome-host interactions in intestinal health and disease
Virome-host interactions in intestinal health and disease
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DOI：
10.1016/j.coviro.2019.06.003
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发表时间：
2019-08-01
影响因子：
5.9
通讯作者：
Kweon, Mi-Na
中科院分区：
文献类型：
--
作者：
Seo, Sang-Uk;Kweon, Mi-Na
肠道病毒组主要由与肠道细菌相关的噬菌体和原噬菌体组成。噬菌体通过靶向其相关细菌间接影响宿主免疫系统;然而，研究表明噬菌体也有不同的途径，使它们能够直接与宿主相互作用。真核病毒的数量比噬菌体少，但在刺激宿主免疫反应方面更有效。急性、永久性和潜伏性病毒感染通过不同类型的模式识别受体检测，并诱导宿主免疫应答，包括抗病毒I型干扰素应答。了解共生微生物与宿主免疫系统之间复杂的相互作用是阐明其在肠道疾病中作用的先决条件。
The enteric virome consists largely of bacteriophages and prophages related to commensal bacteria. Bacteriophages indirectly affect the host immune system by targeting their associated bacteria; however, studies suggest that bacteriophages also have distinct pathways that enable them to interact directly with the host. Eukaryotic viruses are less abundant than bacteriophages but are more efficient in the stimulation of host immune responses. Acute, permanent, and latent viral infections are detected by different types of pattern recognition receptors and induce host immune responses, including the antiviral type I interferon response. Understanding the complex interplay between commensal microorganisms and the host immune system is a prerequisite to elucidating their role in intestinal diseases.