Genome reduction of Borrelia burgdorferi: two TCS signaling pathways for two distinct host habitats.
Genome reduction of Borrelia burgdorferi: two TCS signaling pathways for two distinct host habitats.
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伯氏疏螺旋体的基因组缩减：两种不同宿主栖息地的两种 TCS 信号通路
DOI：
10.1007/s11427-015-4996-z
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发表时间：
2016-01
期刊：
影响因子：
--
通讯作者：
Yang XF
中科院分区：
文献类型：
--
作者：
Ye M;Zhou Y;Lou Y;Yang XF
莱姆病是一种在美国、欧洲和亚洲（包括中国）新兴的蜱传疾病，已成为欧洲和北美最常见的媒介传播疾病。感染是由螺旋体病原体伯氏疏螺旋体引起的，通过蜱叮咬传播。莱姆病的临床表现范围从发热和皮肤损伤（游走性红斑）到多系统病症，如关节炎、心脏炎和神经疏螺旋体病（Steere等人，2004年）。虽然可以用抗生素治疗，但感染诊断不足，莱姆病的晚期很难治疗，没有商业疫苗。另一种策略是阻断B的传输。burgdorferi。了解B.将burgdorferi维持在地方性循环中是这一策略的关键。burgdorferi维持在包含两种明显不同的宿主（节肢动物载体和哺乳动物宿主）的地方病循环中（Radolf等，2012; Samuels，2011）。B。burgdorferi必须能够适应两种不同的宿主环境。另一方面，作为一种非自由活病原体，B. burgdorferi的基因组显著减少。很明显，B。burgdorferi在利用其有限的基因组能力以适应这两种宿主环境并在其中生存方面已经进化。因此，B。burgdorferi为研究信号转导和宿主适应机制提供了一个极好的系统。在这方面，细菌双组分系统（TCS）是细菌用来感知和响应环境条件的主要信号通路。典型的TCS由作为传感器的组氨酸激酶和介导细胞应答的相应应答调节剂组成（Stock等人，2000年）。大多数细菌有许多TCS系统。例如，大肠杆菌有超过30个TCS。相反，B. Burgdorferi基因组仅具有两个TCS（除了趋化性CheA-CheY系统之外），Hk 1-Rrp 1和Hk 2-Rrp 2。考虑到B.伯氏菌在其整个生命周期中遇到两个宿主，可能是B。burgdorferi已经进化到使用这两种TCS在每个宿主中生存？
Lyme disease is an emerging tick-borne disease in the US, Europe, and Asia including China, and has become the most common vector-borne disease in both Europe and North America. Infection is caused by the spirochetal pathogen Borrelia burgdorferi sensu lato, transmitted via tick bites. The clinical manifestations of Lyme disease range from fever and skin lesions (erythema migrans) to multisystem disorders such as arthritis, carditis, and neuroborreliosis (Steere et al., 2004). Although treatable with antibiotics, the infection is underdiagnosed, and the late stages of Lyme disease are difficult to treat. No commercial vaccine is available. An alternative strategy is to block the transmission of B. burgdorferi. Understanding how B. burgdorferi is maintained in the enzootic cycle is the key for such strategy.B. burgdorferi is maintained in an enzootic cycle containing two markedly different hosts, an arthropod vector and a mammalian host (Radolf et al., 2012; Samuels, 2011). B. burgdorferi must be able to adapt to both distinct host environments. On the other hand, as a non-free living pathogen, B. burgdorferi has a dramatically reduced genome. Remarkably, B. burgdorferi has evolved in utilizing its limited genomic capabilities to adapt to and survive in these two host environments. Therefore, B. burgdorferi provides a wonderful system to study mechanism of signal transduction and host adaptation. In this regard, bacterial twocomponent systems (TCSs) are the main signaling pathways that bacteria utilize to sense and respond to environmental conditions. A typical TCS consists of a histidine kinase as a sensor and a corresponding response regulator that mediates the cellular response (Stock et al., 2000). Most bacteria have many TCS systems. For example, Escherichia coli has over 30 TCSs. In contrast, the B. burgdorferi genome only has two TCSs,(in addition to the chemotactic CheA-CheY system), Hk1-Rrp1 and Hk2-Rrp2. Considering that B. burgdorferi encounters two hosts throughout its life cycle, could B. burgdorferi have evolved to employ these two TCSs to survive in each of the hosts?
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影响因子：
6.7
作者：
Pappas CJ;Iyer R;Petzke MM;Caimano MJ;Radolf JD;Schwartz I
通讯作者：
Schwartz I
影响因子：
3.1
作者：
Caimano, Melissa J.;Dunham-Ems, Star;Radolf, Justin D.
通讯作者：
Radolf, Justin D.
影响因子：
3.1
作者：
Sze, Ching Wooen;Smith, Alexis;Li, Chunhao
通讯作者：
Li, Chunhao
影响因子：
3.6
作者：
Kostick JL;Szkotnicki LT;Rogers EA;Bocci P;Raffaelli N;Marconi RT
通讯作者：
Marconi RT
影响因子：
3.6
作者：
Miller CL;Karna SL;Seshu J
通讯作者：
Seshu J