Generalized pustular psoriasis triggered by Zika virus infection
Generalized pustular psoriasis triggered by Zika virus infection
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DOI：
10.1111/ced.13294
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发表时间：
2018-03
影响因子：
4.1
通讯作者：
A. E. P. Mondolfi;M. H. Perez;Gabriela M. Blohm;Marlys Marquez;A. M. Mendoza;C. Hernandez-Pereira;Maritza Escalona;A. L. Colatosti;J. R. DeArocha;A. J. R. Morales
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文献类型：
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作者：
A. E. P. Mondolfi;M. H. Perez;Gabriela M. Blohm;Marlys Marquez;A. M. Mendoza;C. Hernandez-Pereira;Maritza Escalona;A. L. Colatosti;J. R. DeArocha;A. J. R. Morales
寨卡病毒是一种新兴的虫媒病毒，其流行比例正在世界热带和亚热带地区扩大。虽然寨卡病毒与许多先天性和神经系统并发症有关，但对ZIKV感染对人类皮肤的影响知之甚少。我们报告了一例68岁女性患者，在之前的ZIKV感染事件后出现全身性脓疱性银屑病。基于皮肤环境中ZIKV感染生物学的最新实验数据，我们推测ZIKV可能通过刺激皮肤环境中角质形成细胞衍生的炎症介质和多功能T细胞驱动的免疫反应直接触发了泛发性脓疱性银屑病的发展。
Zika virus is an emerging arbovirus, which is expanding in epidemic proportions through tropical and subtropical areas of the world. Although Zika is linked to a number of congenital and neurological complications, there is scarce knowledge on the impact of ZIKV infection in human skin. We report the case of a 68‐year old woman who presented with generalized pustular psoriasis after a preceding and otherwise uneventful episode of ZIKV infection. Based on recent experimental data on the biology of ZIKV infection in the cutaneous environment, we speculate that ZIKV may have directly triggered the development of generalized pustular psoriasis by stimulation of keratinocyte‐derived mediators of inflammation and a polyfunctional T‐cell driven immune reaction in the cutaneous milieu.