ADAPTIVE EVOLUTION IN THE RAT OLFACTORY RECEPTOR GENE FAMILY
ADAPTIVE EVOLUTION IN THE RAT OLFACTORY RECEPTOR GENE FAMILY
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DOI：
10.1007/bf00160480
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发表时间：
1993-03-01
影响因子：
3.9
通讯作者：
HUGHES, MK
中科院分区：
文献类型：
--
作者：
HUGHES, AL;HUGHES, MK
对大鼠 (Rattusnorvegicus) 嗅觉受体基因家族 DNA 序列的比较揭示了编码该蛋白第二个胞外结构域 (E2) 的基因区域中存在不寻常的核苷酸取代模式。在该结构域中，该亚家族成员之间引起氨基酸残基极性变化的非同义核苷酸差异比不引起极性变化的非同义差异频率高四倍以上。这种非随机的核苷酸取代模式是过去定向选择有利于该亚家族成员中 E2 结构域多样化的证据。这反过来表明E2可能在嗅觉受体家族每个成员独特的功能中发挥一些重要作用，并且它可能是气味结合域。
Comparison of DNA sequences of the rat (Rattus norvegicus) olfactory receptor gene family revealed an unusual pattern of nucleotide substitution in the gene region encoding the second extracellular domain (E2) of the protein. In this domain, nonsynonymous nucleotide differences between members of this subfamily that caused a change in amino acid residue polarity were over four times more frequent than nonsynonymous differences that did not cause a polarity change. This nonrandom pattern of nucleotide substitution is evidence of past directional selection favoring diversification of the E2 domain among members of this subfamily. This in tum suggests that E2 may play some important role in the functions unique to each member of the olfactory receptor family, and that it may perhaps be an odorant binding domain.