Reduced Expression of Voltage-Gated Sodium Channel Beta 2 Restores Neuronal Injury and Improves Cognitive Dysfunction Induced by Aβ1-42.
Reduced Expression of Voltage-Gated Sodium Channel Beta 2 Restores Neuronal Injury and Improves Cognitive Dysfunction Induced by Aβ1-42.
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电压门控钠通道 Beta 2 表达减少可恢复神经元损伤并改善 Aβ1-42 引起的认知功能障碍。
DOI：
10.1155/2022/3995227
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发表时间：
2022
影响因子：
3.1
通讯作者：
Xiyang, Yan-Bin
中科院分区：
文献类型：
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作者：
Li, Shan;Yan, Guo-Ji;Tan, Ya-Xin;Xue, Lu-Lu;Wang, Ting-Hua;Zhao, Hao-Ran;Lu, Min-Nan;Zhang, Hui-Xiang;Mei, Rong;Dong, Xiao-Han;Liu, Li-Na;Wang, Dan;Xiyang, Yan-Bin
电压门控钠通道β2(NAV 2.2或NAVβ2，由SCN2BmRNA编码)参与维持前额叶皮质和海马区的正常生理功能，可能与前额叶皮质衰老和记忆减退有关。本研究探讨了Navβ2在淀粉样蛋白-β1-42-(Aβ1-42-)诱导的神经损伤模型中的作用及其可能的分子机制。结果表明，Navβ2基因敲除能恢复Aβ1-42诱导的神经元存活，增加脑源性神经营养因子含量、NEP蛋白含量和NEP酶活性，并有效改变淀粉样前体蛋白(APP)代谢物Aβ42、SAPα和SAPβ的比例，从而改善认知功能障碍。这可能是通过调节NEP转录和APP代谢，加速Aβ降解，减轻神经元损伤，调节脑源性神经营养因子相关信号通路修复神经元突触效率来实现的。本研究为NAVβ2在体内和体外Aβ1-42诱导的神经元损伤修复中发挥重要作用提供了新的证据。
Voltage-gated sodium channel beta 2 (Nav2.2 or Navβ2, coded by SCN2B mRNA), a gene involved in maintaining normal physiological functions of the prefrontal cortex and hippocampus, might be associated with prefrontal cortex aging and memory decline. This study investigated the effects of Navβ2 in amyloid-β 1-42- (Aβ1-42-) induced neural injury model and the potential underlying molecular mechanism. The results showed that Navβ2 knockdown restored neuronal viability of Aβ1-42-induced injury in neurons; increased the contents of brain-derived neurotrophic factor (BDNF), enzyme neprilysin (NEP) protein, and NEP enzyme activity; and effectively altered the proportions of the amyloid precursor protein (APP) metabolites including Aβ42, sAPPα, and sAPPβ, thus ameliorating cognitive dysfunction. This may be achieved through regulating NEP transcription and APP metabolism, accelerating Aβ degradation, alleviating neuronal impairment, and regulating BDNF-related signal pathways to repair neuronal synaptic efficiency. This study provides novel evidence indicating that Navβ2 plays crucial roles in the repair of neuronal injury induced by Aβ1-42 both in vivo and in vitro.
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影响因子：
4
作者：
Gahete, Manuel D.;Rubio, Alicia;Castano, Justo P.
通讯作者：
Castano, Justo P.
影响因子：
3.9
作者：
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影响因子：
--
作者：
Jantaratnotai N;Ryu JK;Schwab C;McGeer PL;McLarnon JG
通讯作者：
McLarnon JG
影响因子：
4.8
作者：
Grimm MO;Mett J;Stahlmann CP;Haupenthal VJ;Zimmer VC;Hartmann T
通讯作者：
Hartmann T
Nav beta 2 敲除通过部分抑制癫痫发作和 APP 淀粉样蛋白加工来改善 APP/PS1 小鼠的认知能力
影响因子：
--
作者：
Hu T;Xiao Z;Mao R;Chen B;Lu MN;Tong J;Mei R;Li SS;Xiao ZC;Zhang LF;Xiyang YB
通讯作者：
Xiyang YB