Recent advances in the understanding of the role of the endocannabinoid system in liver diseases.
Recent advances in the understanding of the role of the endocannabinoid system in liver diseases.
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DOI：
10.1016/j.dld.2010.08.010
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发表时间：
2011-03
影响因子：
4.5
通讯作者：
DeMorrow, Sharon
中科院分区：
文献类型：
--
作者：
Huang, Li;Quinn, Matthew A.;Frampton, Gabriel A.;Golden, Lessie Eric;DeMorrow, Sharon
内源性大麻素是普遍存在的信号分子，通过许多特定的大麻素受体发挥其作用。最近的研究表明，这种内源性大麻素系统参与了与急性和慢性肝病相关的病理生理过程，以及这些疾病引起的并发症，如肝性脑病和心脏问题。靶向这种信号系统在改善这些肝脏疾病的实验模型中的一些症状和后果方面是有用的。这篇综述总结了我们对内源性大麻素在肝脏疾病中的认识和理解的最新进展，并强调了可能对治疗这些疾病有用的潜在新治疗策略
Endocannabinoids are ubiquitous signaling molecules that exert their effects through a number of specific cannabinoid receptors. Recent studies have indicated that this endocannabinoid system is involved in the pathophysiological processes associated with both acute and chronic liver diseases as well as in the complications that arise from these diseases such as hepatic encephalopathy and cardiac problems. Targeting this signaling system has been useful in ameliorating some of the symptoms and consequences in experimental models of these liver diseases. This review summarizes the recent advances into our knowledge and understanding of endocannabinoids in liver diseases and highlights potential novel therapeutic strategies that may prove useful to treat these diseases
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影响因子：
82.9
作者：
Galve-Roperh, I;Sánchez, C;Guzmán, M
通讯作者：
Guzmán, M
影响因子：
6.1
作者：
Glaser, ST;Kaczocha, M;Deutsch, DG
通讯作者：
Deutsch, DG
DOI：
10.1016/j.beem.2008.10.009
发表时间：
2009-02-01
影响因子：
7.4
作者：
Caraceni, Paolo;Domenicali, Marco;Bernardi, Mauro
通讯作者：
Bernardi, Mauro
影响因子：
3.7
作者：
Frampton, Gabriel;Coufal, Monique;DeMorrow, Sharon
通讯作者：
DeMorrow, Sharon
影响因子：
64.8
作者：
Calignano, A;La Rana, G;Piomelli, D
通讯作者：
Piomelli, D