Endoscopic ultrasound guided fine needle aspiration biopsy in diagnosis of pancreatic and peripancreatic lesions: a single center experience in Korea.
Endoscopic ultrasound guided fine needle aspiration biopsy in diagnosis of pancreatic and peripancreatic lesions: a single center experience in Korea.
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DOI：
10.5009/gnl.2009.3.2.116
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发表时间：
2009-06
期刊：
影响因子：
3.4
通讯作者：
Kim MH
中科院分区：
文献类型：
--
作者：
Hwang CY;Lee SS;Song TJ;Moon SH;Lee D;Park DH;Seo DW;Lee SK;Kim MH
虽然超声内窥镜引导下细针抽吸术(EUS-FNA)在韩国已被引进并得到越来越多的应用，但有关其性能的报道并不多见。这项研究的目的是评估没有现场细胞病理学专家的EUS-FNA在建立韩国单一机构的胰腺和胰周实性肿块诊断中的作用。对2007年139例胰腺及胰周实性肿块行EUS-FNA治疗的病历进行了回顾性分析。通过对细胞学诊断与最终诊断的比较，确定诊断的敏感性、特异性和准确性，并分析影响准确性的因素和并发症。139例中有120例确诊为恶性肿瘤。EUS-FNA的敏感性、特异性和准确性分别为82%、89%和83%，阳性预测值和阴性预测值分别为100%和46%。多因素分析显示，影响FNA准确性的因素中，病灶大小差异有统计学意义(p值0.08)。没有现场细胞病理学专家的EUS-FNA被发现是准确和安全的，因此EUS-FNA应该成为胰腺和胰周肿块标准处理算法的一部分。
Although endoscopic ultrasound guided fine needle aspiration (EUS-FNA) has been introduced and its use has been increasing in Korea, there have not been many reports about its performance. The aim of this study was to assess the utility of EUS-FNA without on-site cytopathologist in establishing the diagnosis of solid pancreatic and peripancreatic masses from a single institution in Korea. Medical records of 139 patients who underwent EUS-FNA for pancreatic and peripancreatic solid mass in the year 2007, were retrospectively reviewed. By comparing cytopathologic diagnosis of FNA with final diagnosis, sensitivity, specificity, and accuracy were determined, and factors influencing the accuracy as well as complications were analyzed. One hundred twenty out of 139 cases had final diagnosis of malignancy. Sensitivity, specificity, and accuracy of EUS-FNA were 82%, 89%, and 83%, respectively, and positive and negative predictive values were 100% and 46%, respectively. As for factors influencing the accuracy of FNA, lesion size was marginally significant (p-value 0.08) by multivariate analysis. EUS-FNA performed without on-site cytopathologist was found to be accurate and safe, and thus EUS-FNA should be a part of the standard management algorithm for pancreatic and peripancreatic mass.
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