DIFFERENTIAL NK CELL AND MACROPHAGE KILLING OF HAMSTER-CELLS INFECTED WITH NONONCOGENIC OR ONCOGENIC ADENOVIRUS
DIFFERENTIAL NK CELL AND MACROPHAGE KILLING OF HAMSTER-CELLS INFECTED WITH NONONCOGENIC OR ONCOGENIC ADENOVIRUS
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DOI：
10.1126/science.6710160
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发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
LEWIS, AM
中科院分区：
文献类型：
--
作者：
COOK, JL;LEWIS, AM
与感染非致癌性2型腺病毒（Ad 2）的细胞相比，感染高致癌性人腺病毒12型（Ad 12）的仓鼠细胞对自然杀伤细胞和巨噬细胞的溶解具有抵抗力。显然，早期腺病毒基因在仓鼠细胞中的表达导致了与体内细胞中的Ad2感染细胞相比，AD12的优先存活，从而为这2种转化病毒的致癌性差异提供了解释。
Hamster cells infected with highly oncogenic human adenovirus type 12 (Ad12) were resistant to lysis by natural killer cells and macrophages, compared to cells infected with nononcogenic adenovirus type 2 (Ad2). Evidently, early adenovirus gene expression in hamster cells results in preferential survival of AD12, compared to Ad2, infected cells in cells in vivo, thus providing an explanation for the differences in the oncogenicities of these 2 transforming viruses.