Evaluation of the lent-soma scales for the prospective assessment of treatment morbidity in cervical carcinoma
Evaluation of the lent-soma scales for the prospective assessment of treatment morbidity in cervical carcinoma
复制标题
DOI：
10.1016/s0360-3016(02)04578-9
复制
发表时间：
2003-06-01
影响因子：
7
通讯作者：
Davidson, SE
中科院分区：
文献类型：
--
作者：
Routledge, JA;Burns, MP;Davidson, SE
目的。采用访谈法和邮寄调查问卷的方法，前瞻性地检验放射治疗(RT)治疗后宫颈癌患者的主观、客观、管理、分析(SOMA)量表的远期疗效，并检验该量表在评价放射治疗效果方面的敏感性。一系列连续的100名患者完成了问卷调查，对发表的Lent-SOMA量表的主观部分进行了评分。在放疗前以及治疗开始后大约21、70、200、400、600和800天进行评估。在完成问卷时，用依从性来检验量表的可接受性和可行性。通过评估两个独立评分者获得的数据的一致性和检查这些量表测量辐射相关症状的能力来验证这些量表。在放疗前对89例患者进行问卷调查。不依从程度为11%。当两个人独立完成问卷调查时，分数之间的一致性非常好。主观评分在治疗后第21天最高，但一般在70天后下降。平均基线总体Lent-SOMA主观评分随着疾病的进展而增加(p=0.008)，并且在单纯RT治疗的患者中更高(p=0.044)。在宫颈癌中，Lent-SOMA评分在临床上是可以接受和可行的，并且适合于从RT中衡量早期主观发病率。(C)2003年爱思唯尔公司。
Purpose. To examine the Late Effects Normal Tissue Task Force (LENT)-Subjective, Objective, Management, Analytic (SOMA) scales prospectively in carcinoma of the cervix treated curatively with radiotherapy (RT) using interviews and postal questionnaires and to test the sensitivity of the scales in assessing the radiation effects.Methods and Materials. A consecutive series of 100 patients completed questionnaires to score the subjective part of the published LENT-SOMA scales. Assessments were made before RT and at approximately 21, 70, 200, 400, 600, and 800 days after the start of treatment. The acceptability and feasibility of using the scales was examined using compliance in completion of the questionnaires. The scales were validated by evaluating the concordance of data obtained by two independent scorers and by examining the ability of the scales to measure radiation-related symptoms.Results. Questionnaires were completed for 89 patients before RT. The level of noncompliance was 11%. The concordance between scores when two people completed the questionnaires independently was excellent. Subjective subsite scores were highest 21 days after treatment but generally fell by 70 days. The average baseline overall LENT-SOMA subjective scores increased with advancing stage (p = 0.008) and were higher for patients treated with RT alone (p = 0.044).Conclusion. In cervical carcinoma, the LENT-SOMA scales were acceptable and feasible to administer in the clinic and appropriate in the measurement of early subjective morbidity from RT. (C) 2003 Elsevier Inc.