Prognostic value of RDW in cancers: a systematic review and meta-analysis.
Prognostic value of RDW in cancers: a systematic review and meta-analysis.
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DOI：
10.18632/oncotarget.13784
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发表时间：
2017-02-28
期刊：
影响因子：
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通讯作者：
Xiong S
中科院分区：
文献类型：
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作者：
Hu L;Li M;Ding Y;Pu L;Liu J;Xie J;Cabanero M;Li J;Xiang R;Xiong S
红细胞分布宽度（RDW）是几十年来用来区分贫血类型的一个参数，最近的研究表明它是各种类型癌症患者的预后因素。然而，RDW在癌症患者中的预后价值仍存在争议。在这里，我们进行了一项荟萃分析和系统综述，以评估RDW在癌症患者中的预后价值。相关研究摘自Web of Science、Embase、Pubmed和Cochrane Library等数据库。总共16篇论文在这个荟萃分析中4267名患者,和合并后的结果表明,升高RDW与贫穷有关生存(OS) (HR = 1.47, 95% ci: 1.29—-1.66),可怜的癌症特异性生存(CSS) (HR = 1.46, 95% ci: 1.08—-1.85),可怜的无病生存期(DFS) (HR = 1.91, 95% ci: 1.27—-2.56),可怜的风平浪静生存(EFS) (HR = 2.98, 95% ci: 0.57—-5.39)和穷人progress-free生存(PFS) (HR = 3.21, 95% ci: 0.33—-6.75)治疗后。此外，在按癌症类型、RDW临界值、样本量和种族分层的亚组分析中也观察到类似的结果。总之，这项荟萃分析表明，RDW可能是癌症患者的潜在预后标志物，高RDW也可能与不良预后相关。
Red blood cell distribution width (RDW), a parameter that used to differentiate the type of anemia for several decades, recent studies suggest it was a prognostic factor in various types of cancer patients. However, the prognostic value of RDW in cancer patients remains controversial. Here, we performed a meta-analysis and systematic review to evaluate the prognostic value of RDW in cancer patients. Relevant studies were picked out from the databases of Web of Science, Embase, Pubmed and Cochrane Library. A total of 16 papers with 4267 patients were included in this meta-analysis, and the combined results indicated that elevated RDW was associated with poor over survival (OS) (HR = 1.47, 95%CI:1.29-1.66), poor cancer-specific survival (CSS) (HR = 1.46, 95%CI:1.08-1.85), poor disease-free survival (DFS) (HR = 1.91, 95%CI:1.27-2.56), poor event-free survival (EFS) (HR = 2.98, 95%CI:0.57-5.39) and poor progress-free survival (PFS) (HR = 3.21, 95%CI:0.33-6.75) after treatment. Furthermore, the similar results were observed in subgroup analysis stratified by cancer type, cutoff value of RDW, sample size and ethnicity. In conclusion, this meta-analysis demonstrated that RDW may be a potential prognostic marker in patients with cancer, and high RDW may also be associated with poor outcomes.