Role of the anterior cingulate and medial orbitofrontal cortex in processing drug cues in cocaine addiction
Role of the anterior cingulate and medial orbitofrontal cortex in processing drug cues in cocaine addiction
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DOI：
10.1016/j.neuroscience.2006.11.024
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发表时间：
2007-02-23
期刊：
影响因子：
3.3
通讯作者：
Volkow, N. D.
中科院分区：
文献类型：
--
作者：
Goldstein, R. Z.;Tomasi, D.;Volkow, N. D.
本研究的目的是设计一种新的功能磁共振成像（fMRI）任务，探讨药物成瘾者在同时执行一项无关任务时，前扣带皮层（ACC）和眶额皮层（OFC）在处理显著性刺激相关线索中的作用。我们在14名可卡因使用障碍患者中使用了一种新的fMRI颜色词药物Stroop任务;受试者必须按下药物的颜色与匹配的中性词。虽然在目前的受试者样本中，药物和中性条件之间没有准确性或速度差异，但药物词比匹配的中性词更负价。此外，与先前使用不同Stroop功能磁共振成像范式的其他精神病理学个体的报告一致，我们更经典的颜色词Stroop设计显示尾背前扣带皮层（cdACC）的双侧激活和吻腹前扣带皮层/内侧眶额皮层（rACC/mOFC）的低激活。与中性词相比，药物引起的rACC/mOFC低激活的趋势更大，但在全脑校正后无法存活。然而，相关分析表明：（1）cdACC药物相关激活越多，药物词的负配价越高（r=-0.86，P < 0.0001），而中性词无显著性差异;（2）rACC/mOFC对药物非中性词的低激活程度越高，对药物非中性词的错误越多（r=0.85，P < 0.0001）。两者合计，结果表明，这一新开发的药物Stroop功能磁共振成像任务可能是一个敏感的生物行为测定的功能招募的反应，以调节显着的神经元相关的刺激在吸毒成瘾的个人。(c)2006年IBRO。由爱思唯尔有限公司出版。保留所有权利。
Our goal in the current report was to design a new functional magnetic resonance imaging (fMRI) task to probe the role of the anterior cingulate cortex (ACC) and orbitofrontal cortex (OFC) in processing of salient symptom-related cues during the simultaneous performance of an unrelated task in drug-addicted persons. We used a novel fMRI color-word drug Stroop task in 14 individuals with cocaine use disorders; subjects had to press for color of drug vs. matched neutral words. Although there were no accuracy or speed differences between the drug and neutral conditions in the current sample of subjects, drug words were more negatively valenced than the matched neutral words. Further, consistent with prior reports in individuals with other psychopathologies using different Stroop fMRI paradigms, our more classical color-word Stroop design revealed bilateral activations in the caudal-dorsal anterior cingulate cortex (cdACC) and hypoactivations in the rostro-ventral anterior cingulate cortex/medial orbitofrontal cortex (rACC/mOFC). A trend for larger rACC/mOFC hypoactivations to the drug than neutral words did not survive whole-brain corrections. Nevertheless, correlation analyses indicated that (1) the more the cdACC drug-related activation, the more negative the valence attributed to the drug words (r=-0.86, P < 0.0001) but not neutral words; and (2) the more the rACC/mOFC hypoactivation to drug minus neutral words, the more the errors committed specifically to the drug minus neutral words (r=0.85, P < 0.0001). Taken together, results suggest that this newly developed drug Stroop fMRI task may be a sensitive biobehavioral assay of the functions recruited for the regulation of responses to salient symptom-related stimuli in drug-addicted individuals. (c) 2006 IBRO. Published by Elsevier Ltd. All rights reserved.