Epithelial localization of antiendometrial antibodies associated with endometriosis.
Epithelial localization of antiendometrial antibodies associated with endometriosis.
复制标题
与子宫内膜异位症相关的抗子宫内膜抗体的上皮定位。
DOI：
10.1111/j.1600-0897.1987.tb00092.x
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Shivers,AC
中科院分区：
文献类型：
--
作者：
Wild,RA;Satyaswaroop,PG;Shivers,AC
抗子宫内膜抗体已在子宫内膜异位症患者中得到证实。为了进一步了解对子宫内膜的免疫改变，分离的腺体和间质单层子宫内膜细胞制剂以及子宫内膜、乳腺癌和卵巢癌细胞系通过间接免疫荧光法检测，利用先前显示有子宫内膜抗体的子宫内膜异位症患者的血清。在1:1至1:16的血清稀释中，与月经周期无关，只有正常子宫内膜的腺（上皮）成分有明显的荧光染色，而基质成分没有。这一发现的意义，因为它涉及到子宫内膜异位症的病理生理学有待进一步研究。
Antiendometrial antibodies have been demonstrated in patients with endometriosis. As a further step in understanding the immunological alterations against the endometrium, isolated glandular and stromal monolayer endometrial cell preparations and endometrial, breast, and ovarian carcinoma cell lines were tested by indirect immunofluorescence assay utilizing sera of patients with endometriosis previously shown to have antibodies against endometrium. In dilutions of serum of 1:1 to 1:16, significant fluorescence staining was noted only in the glandular (epithelial) component and not in the stromal component of normal endometrium without regard to phase of the menstrual cycle. The significance of this finding as it relates to the pathophysiology of endometriosis awaits further study.