Recent Advances in Biocatalytic Promiscuity: Hydrolase-Catalyzed Reactions for Nonconventional Transformations
Recent Advances in Biocatalytic Promiscuity: Hydrolase-Catalyzed Reactions for Nonconventional Transformations
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DOI：
10.1002/tcr.201500008
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发表时间：
2015-08-01
期刊：
影响因子：
6.6
通讯作者：
Gotor-Fernandez, Vicente
中科院分区：
文献类型：
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作者：
Lopez-Iglesias, Maria;Gotor-Fernandez, Vicente
近几十年来，酶已成为在温和的反应条件下进行合成转化的理想催化剂。它们具有很高的选择性和广泛的底物专一性，能够加速无数的生物转化，包括极好的原子经济性，目前已得到充分认识。这六类酶(氧化还原酶、转移酶、水解酶、裂解酶、异构酶和连接酶)具有出色的能力对靶分子进行特定的修饰。然而，在过去的15年里，出现了与各种类别的生物催化剂催化的非常规过程有关的新例子。其中，水解酶由于在碳-碳和碳-杂原子键形成反应、氧化过程和新的水解性转化等最初意想不到的反应中表现出显著的活性而受到特别的关注。在这篇综述中，将披露这一领域的主要发现，强调水解酶的催化特性不仅可以催化单一过程，还可以催化多组分和串联的非常规反应。
Enzymes have emerged in recent decades as ideal catalysts for synthetic transformations under mild reaction conditions. Their capacity to accelerate a myriad of biotransformations with high levels of selectivity and broad substrate specificity including excellent atom economy has led to a current full recognition. The six classes of enzymes (oxidoreductases, transferases, hydrolases, lyases, isomerases and ligases) possess outstanding abilities to perform specific modifications in target molecules. Nevertheless, in the last fifteen years, novel examples have appeared related to nonconventional processes catalyzed by various classes of biocatalysts. Amongst these, hydrolases have received special attention since they display remarkable activities in initially unexpected reactions such as carbon-carbon and carbon-heteroatom bond-formation reactions, oxidative processes and novel hydrolytic transformations. In this review, the main findings in this area will be disclosed, highlighting the catalytic properties of hydrolases not only to catalyze single processes but also multicomponent and tandem nonconventional reactions.