Insomnia in Vietnam era veteran twins: influence of genes and combat experience.
Insomnia in Vietnam era veteran twins: influence of genes and combat experience.
复制标题
越战时期老兵双胞胎的失眠：基因和战斗经验的影响。
作者：
McCarren,M;Goldberg,J;Ramakrishnan,V;Fabsitz,R
研究人员在2,825对越战老兵男性双胞胎中研究了遗传和环境对失眠的影响。研究中自我报告的睡眠问题包括入睡困难、难以保持睡眠、经常醒来、醒来时很累和复合睡眠量表。同卵双胞胎的睡眠问题的相关性大于异卵双胞胎，遗传度估计值在0.21到0.42之间。共同的家庭环境没有影响。战斗经验和睡眠问题的表型相关性很小，范围从0.00到0.09，在同卵双胞胎和异卵双胞胎中没有差异。当同时评估基因和战斗暴露的影响时，所有睡眠指标都有显着的遗传贡献，但战斗暴露仅与整体睡眠质量显着相关，经常醒来，难以保持睡眠。
Genetic and environmental influences on insomnia were studied in 2,825 pairs of Vietnam era veteran male twins. The self-reported sleep problems studied included trouble falling asleep, trouble staying asleep, waking often, waking tired and a composite sleep scale. Twin correlations for each of the sleep problems were larger in monozygotic than in dizygotic pairs, with heritability estimates ranging from 0.21 to 0.42. There was no effect of common familial environment. Phenotypic correlations for combat experience and sleep problems were small, ranging from 0.00 to 0.09, with no differences seen in monozygotic and dizygotic twins. When the effects of genes and combat exposure were evaluated simultaneously, there was a significant genetic contribution to all sleep measures, but combat exposure was significantly associated only with overall sleep quality, waking often and having trouble staying asleep.