Comparison of transplanted islets in patients with functioning versus nonfunctioning allografts.
Comparison of transplanted islets in patients with functioning versus nonfunctioning allografts.
复制标题
有功能的同种异体移植物患者与无功能的同种异体移植物患者的移植胰岛的比较。
DOI：
10.1016/s0041-1345(97)00315-1
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发表时间：
1997
影响因子：
0.9
通讯作者：
Scharp,DW
中科院分区：
文献类型：
--
作者：
Swanson,CJ;Olack,BJ;Flavin,KS;Mohanakumar,T;Brennan,DC;White,NH;Lacy,PE;Scharp,DW
自1985年以来，圣路易斯的华盛顿大学医学院（WUMS）进行了27例移植，与伦敦的西安大略大学和安大略大学一起进行了4例移植。大多数成功的移植发生在1989年，当时我们进入了更好的免疫抑制，早期强化胰岛素治疗，更纯净的制剂，通过24 ℃培养进行免疫改变，以及冷冻保存导致更大的移植胰岛制剂的时代。在WUMS最广泛随访的两组患者是已建立肾移植后进行胰岛移植的患者（EKI，n= 8）和同时接受肾移植和胰岛移植的患者（SKI，n= 9）。关于胰岛移植的一些争议仍然存在。例如，胰岛移植应该与肾移植同时进行还是在肾移植之后进行？冷冻保存和/或胰岛培养对胰岛功能有影响吗？人类白细胞抗原（HLA）配型的作用是什么？胰岛质量是否改善或妨碍长期胰岛功能？这里介绍的是一项针对我们的EKI和SKI患者的回顾性研究的结果。
Since 1985, 27 transplants have occurred at Washington University School of Medicine (WUMS) in St. Louis and 4 transplants in conjunction with the University of Western Ontario, London, Ontario. The majority of successful transplants have occurred since 1989 when we entered into the era of better immunosuppression, early intensive insulin therapy, purer preparations, immunoalteration by 24 C culture, and cryopreservation resulting in larger transplanted islet preparations. The two groups of patients most extensively followed at WUMS were patients with established kidney grafts followed by islet transplant (EKI, n= 8) and those receiving simultaneously transplanted kidney and islet transplant (SKI, n= 9). Several controversies concerning islet transplantation still exist. For example, should islet transplantation occur simultaneous with or following renal transplant? Does cryopreservation and/or islet culture make a difference in islet function? What is the role of human leukocyte antigen (HLA) matching? Does islet mass improve or hamper long-term islet function? Presented here are the results of a retrospective study addressing these questions in regard to our EKI and SKI patients.