MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder.
MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder.
复制标题
DOI：
10.1176/ajp.152.7.973
复制
发表时间：
1995-07
期刊：
影响因子：
--
通讯作者：
J. Bremner;P. Randall;T. Scott;R. Bronen;J. Seibyl;S. Southwick;R. Delaney;G. McCarthy;D. Cha
中科院分区：
文献类型：
--
作者：
J. Bremner;P. Randall;T. Scott;R. Bronen;J. Seibyl;S. Southwick;R. Delaney;G. McCarthy;D. Cha
目的 对非人类灵长类动物的研究表明，与压力相关的高水平皮质醇对海马体有神经毒性作用，海马体是一种参与记忆的大脑结构。作者先前发现，与战斗相关的创伤后应激障碍（PTSD）患者存在短期记忆缺陷。本研究的目的是比较创伤后应激障碍患者与无精神障碍受试者的海马体体积。
方法 采用磁共振成像技术测量26名患有创伤后应激障碍的越战退伍军人以及22名在年龄、性别、种族、受教育年限、社会经济地位、体型和酗酒年限等方面与患者相似的对照受试者的海马体体积。
结果 与对照受试者相比，创伤后应激障碍患者右侧海马体体积在统计学上显著小8%，但其他大脑区域（尾状核和颞叶）的体积没有差异。仅在创伤后应激障碍患者中，用韦氏记忆量表测量的短期言语记忆缺陷与右侧海马体体积较小有关。
结论 这些发现与创伤后应激障碍患者右侧海马体体积较小且与言语记忆功能缺陷有关是一致的。
OBJECTIVE Studies in nonhuman primates suggest that high levels of cortisol associated with stress have neurotoxic effects on the hippocampus, a brain structure involved in memory. The authors previously showed that patients with combat-related posttraumatic stress disorder (PTSD) had deficits in short-term memory. The purpose of this study was to compare the hippocampal volume of patients with PTSD to that of subjects without psychiatric disorder. METHOD Magnetic resonance imaging was used to measure the volume of the hippocampus in 26 Vietnam combat veterans with PTSD and 22 comparison subjects selected to be similar to the patients in age, sex, race, years of education, socioeconomic status, body size, and years of alcohol abuse. RESULTS The PTSD patients had a statistically significant 8% smaller right hippocampal volume relative to that of the comparison subjects, but there was no difference in the volume of other brain regions (caudate and temporal lobe). Deficits in short-term verbal memory as measured with the Wechsler Memory Scale were associated with smaller right hippocampal volume in the PTSD patients only. CONCLUSIONS These findings are consistent with a smaller right hippocampal volume in PTSD that is associated with functional deficits in verbal memory.