LACK OF AIRWAY RESPONSE TO NASAL IRRITATION IN NORMAL AND ASTHMATIC SUBJECTS
LACK OF AIRWAY RESPONSE TO NASAL IRRITATION IN NORMAL AND ASTHMATIC SUBJECTS
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DOI：
10.1111/j.1445-5994.1990.tb01317.x
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发表时间：
1990-08-01
期刊：
影响因子：
--
通讯作者：
SAUNDERS, NA
中科院分区：
文献类型：
--
作者：
LEVI, CR;TYLER, GR;SAUNDERS, NA
Twenty two subjects (10 normals, nine asthmatics and three who had suggestive histories for asthma but normal bronchial histamine challenges) underwent nasal challenges with logarithmic incremental doses of histamine or saline on alternate days. Nasal resistance (measured by posterior rhinometry), and forced expiratory volume in one second (FEV1) were assessed after each dose of nasal histamine or placebo. After each nasal challenge (maximum nasal dose of 250 .mu.g of histamine or doubling of nasal resistance) bronchial responsiveness was measured with a bronchial histamine challenge. Despite significant changes in nasal resistance with nasal histamine (p < 0.01) there was no significant change in the forced expiratory volume in one second, or in bronchial responsiveness. We were unable to demonstrate nasobronchial reflexes initiated by acute irritation of the nasal mucosa with histamine in either normal subjects or in those with mild to moderate asthma.
