Inflammatory potential of the diet and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
Inflammatory potential of the diet and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
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DOI：
10.1093/ajcn/nqy002
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发表时间：
2018-04-01
影响因子：
7.1
通讯作者：
Jakszyn, Paula
中科院分区：
文献类型：
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作者：
Agudo, Antonio;Cayssials, Valerie;Jakszyn, Paula
慢性炎症在两种主要类型的胃癌的发病机制中起关键作用。几种食物、营养素和非营养食物成分似乎参与了慢性炎症的调节。我们评估了饮食的炎症潜力与胃癌风险之间的关系，总体上和2个主要亚位点：贲门癌和非贲门癌。共476，160例受试者对来自欧洲癌症与营养调查（EPIC）研究的30%男性，70%女性患者进行了为期14年的随访，在此期间确定了913例胃癌发病病例，包括236例位于贲门，341例位于胃远端（非贲门），336例肿瘤部位重叠或未知。通过饮食炎症评分（ISD）评估饮食炎症潜力，使用28种饮食成分及其相应的炎症评分计算。ISD和胃癌风险之间的关系通过HR和95%CI进行评估，HR和95%CI通过校正混杂因素的多变量考克斯回归模型计算。所有胃癌、贲门癌和非贲门癌ISD每增加1 SD的HR（95% CI）分别为1.25（1.12，1.39）、1.30（1.06，1.59）和1.07（0.89，1.28）。ISD的最高和最低四分位数的相应值分别为1.66（1.26，2.20）、1.94（1.14，3.30）和1.07（0.70，1.70）。这种模式似乎更一致的胃癌位于贲门比那些位于远端gastre.This研究被列入ISRCTN注册ISRCTN12136108。
Chronic inflammation plays a critical role in the pathogenesis of the 2 major types of gastric cancer. Several foods, nutrients, and nonnutrient food components seem to be involved in the regulation of chronic inflammation.We assessed the association between the inflammatory potential of the diet and the risk of gastric carcinoma, overall and for the 2 major subsites: cardia cancers and noncardia cancers.A total of 476,160 subjects (30% men, 70% women) from the European Investigation into Cancer and Nutrition (EPIC) study were followed for 14 y, during which 913 incident cases of gastric carcinoma were identified, including 236 located in the cardia, 341 in the distal part of the stomach (noncardia), and 336 with overlapping or unknown tumor site. The dietary inflammatory potential was assessed by means of an inflammatory score of the diet (ISD), calculated with the use of 28 dietary components and their corresponding inflammatory scores. The association between the ISD and gastric cancer risk was estimated by HRs and 95% CIs calculated by multivariate Cox regression models adjusted for confounders.The inflammatory potential of the diet was associated with an increased risk of gastric cancer. The HR (95% CI) for each increase in 1 SD of the ISD were 1.25 (1.12, 1.39) for all gastric cancers, 1.30 (1.06, 1.59) for cardia cancers, and 1.07 (0.89, 1.28) for noncardia cancers. The corresponding values for the highest compared with the lowest quartiles of the ISD were 1.66 (1.26, 2.20), 1.94 (1.14, 3.30), and 1.07 (0.70, 1.70), respectively.Our results suggest that low-grade chronic inflammation induced by the diet may be associated with gastric cancer risk. This pattern seems to be more consistent for gastric carcinomas located in the cardia than for those located in the distal stomach.This study is listed on the ISRCTN registry as ISRCTN12136108.