Splenectomy protects aged mice from injury after experimental stroke.
Splenectomy protects aged mice from injury after experimental stroke.
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DOI：
10.1016/j.neurobiolaging.2017.09.022
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发表时间：
2018-01
影响因子：
4.2
通讯作者：
McCullough LD
中科院分区：
文献类型：
--
作者：
Chauhan A;Al Mamun A;Spiegel G;Harris N;Zhu L;McCullough LD
与年轻受试者相比，老年中风患者和老年动物实验性中风的功能恢复明显较差，死亡率较高。已知外周免疫系统的激活会影响卒中结局。先前的研究表明，脾切除术可以减少年轻小鼠的缺血性脑损伤。由于免疫功能随着年龄的增长而变化，目前还不清楚脾切除术是否会在老年动物中产生类似的益处。本实验观察了老年雄性小鼠脑缺血后脾脏在脑损伤中的作用。老年小鼠脾脏结构和免疫细胞组成发生改变。中风前两周脾切除可改善老年雄性小鼠的神经行为和梗死结局。此外，在老年脾切除小鼠中风后，外周免疫细胞向脑内浸润减少，外周炎性细胞因子水平降低。再灌注后立即脾切除术也改善了行为和梗死结局。这项研究表明，抑制脾脏免疫反应是老年人中风治疗的一个预防性相关目标。
Elderly stroke patients and aged animals subjected to experimental stroke have significantly worse functional recovery and higher mortality compared to younger subjects. Activation of the peripheral immune system is known to influence stroke outcome. Prior studies have shown that splenectomy reduces ischemic brain injury in young mice. As immune function changes with aging, it is unclear whether splenectomy will confer similar benefits in aged animals. We investigated the contribution of spleen to brain injury after cerebral ischemia in aged male mice. Splenic architecture and immune cell composition were altered in aged mice. Splenectomy two weeks before stroke resulted in improved neurobehavioral and infarct outcomes in aged male mice. In addition, there was a reduction in peripheral immune cell infiltration into the brain and decreased levels of peripheral inflammatory cytokines after stroke in aged splenectomized mice. Splenectomy immediately after reperfusion also improved behavioral and infarct outcomes. This study suggests that inhibition of the splenic immune response is a translationally relevant target to pursue for stroke treatment in aged individuals.
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影响因子：
0.6
作者：
Dragomir, Mihnea;Petrescu, George Emil Dragos;Vasilescu, Catalin
通讯作者：
Vasilescu, Catalin
影响因子：
3.5
作者：
Farahi N;Paige E;Balla J;Prudence E;Ferreira RC;Southwood M;Appleby SL;Bakke P;Gulsvik A;Litonjua AA;Sparrow D;Silverman EK;Cho MH;Danesh J;Paul DS;Freitag DF;Chilvers ER
通讯作者：
Chilvers ER
DOI：
10.1590/1678-775720150540
发表时间：
2016-05
期刊：
Journal of applied oral science : revista FOB
影响因子：
--
作者：
Knob CD;Silva M;Gasparoto TH;Oliveira CE;Amôr NG;Arakawa NS;Costa FB;Campanelli AP
通讯作者：
Campanelli AP
DOI：
10.1016/j.bbi.2016.01.017
发表时间：
2016-11
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Chesnokova V;Pechnick RN;Wawrowsky K
通讯作者：
Wawrowsky K
影响因子：
3.3
作者：
Dotson, Abby L.;Wang, Jianming;Saugstad, Julie;Murphy, Stephanie J.;Offner, Halina
通讯作者：
Offner, Halina