Glioma-initiating cells: A predominant role in microglia/macrophages tropism to glioma
Glioma-initiating cells: A predominant role in microglia/macrophages tropism to glioma
复制标题
胶质瘤起始细胞：在小胶质细胞/巨噬细胞向胶质瘤趋向性中起主要作用
DOI：
10.1016/j.jneuroim.2010.10.011
复制
发表时间：
2011-03-01
影响因子：
3.3
通讯作者：
Feng, Hua
中科院分区：
文献类型：
--
作者：
Yi, Liang;Xiao, Hualiang;Feng, Hua
癌症起始细胞和癌症相关炎症之间的关系尚不清楚。探讨胶质瘤起始细胞(GIC)和肿瘤相关小胶质细胞/巨噬细胞(/ms)之间的相互作用可能为我们进一步了解胶质瘤的炎症反应和GIC生态位的细胞/分子特征提供机会。在此，我们报道了/MS的浸润率与GIC的密度呈正相关。GICs对/MS的体外募集能力强于黏附性胶质瘤细胞(AGCs)。体内实验表明，GIC形成的种植体具有比AGCs更高的/M渗透水平。我们的研究表明，GICs在小胶质细胞/巨噬细胞对胶质瘤的趋向性中起主导作用，并且GICs的分布与/MS密切相关。作为癌症相关炎症的重要组成部分，/MS可能参与了GIC生态位的构建。(C)2010爱思唯尔B.V.保留所有权利。
The relationship between cancer-initiating cells and cancer-related inflammation is unclear. Exploring the interaction between glioma-initiating cells (GICs) and tumor-associated microglia/macrophages (TAM/Ms) may offer us an opportunity to further understand the inflammatory response in glioma and the cellular/molecular features of the GIC niche. Here we reported a positive correlation between the infiltration of TAM/Ms and the density of GICs. The capacity of GICs to recruit TAM/Ms was stronger than that of adhesive glioma cells (AGCs) in vitro. In vivo experiments suggested that implantations formed by GICs had a higher level of TAM/M infiltration than those formed by AGCs. Our studies indicate a predominant role of GICs in microglia/macrophages tropism to glioma and a close positive correlation between the distribution of GICs and TAM/Ms. As an important part of cancer-related inflammation, TAM/Ms may participate in the architecture of the GIC niche. (C) 2010 Elsevier B.V. All rights reserved.