Role of notch signaling in osteoimmunology-from the standpoint of osteoclast differentiation
Role of notch signaling in osteoimmunology-from the standpoint of osteoclast differentiation
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DOI：
10.1093/ejo/cjs002
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发表时间：
2013-04-01
影响因子：
2.6
通讯作者：
Ren, Yijin
中科院分区：
文献类型：
--
作者：
Duan, Li;Ren, Yijin
Notch信号通路是存在于大多数多细胞生物中的高度保守的细胞信号系统。骨免疫学包括免疫系统和骨代谢之间的相互作用。破骨细胞是一种吸收骨的细胞，在骨代谢中起着至关重要的作用。在这篇综述中，我们讨论了Notch信号在骨免疫学中的作用，这是至关重要的生理性骨重建（如在正畸牙齿移动，骨重建是在平衡）和过度的非生理性Notch信号导致病理性骨重建（如在类风湿性关节炎和牙周炎，骨重建是不平衡的）从破骨细胞分化的角度来看。提出Notch信号不仅控制免疫系统反应，而且干扰参与骨重建过程的破骨细胞分化。因此，Notch信号传导可能是在将免疫系统与骨骼系统交联的条件下有希望的治疗靶标。
The Notch signaling pathway is a highly conserved cell signaling system present in most multicellular organisms. Osteoimmunology comprises the interplay between the immune system and bone metabolism. Osteoclasts, cells that resorb bone, play a crucial role in bone metabolism. In this review, we discuss the role of Notch signaling in osteoimmunology that is crucial for physiological bone remodeling (such as in orthodontic tooth movement, where bone remodeling is in balance) and undue non-physiological Notch signaling which results in pathological bone remodeling (such as in rheumatoid arthritis and periodontitis, where bone remodeling is out of balance) from the point view of osteoclast differentiation. A proposal is made that Notch signaling not only controls immune system reaction but also interferes with osteoclast differentiation involved in the bone remodeling process. Therefore, Notch signaling could be a promising therapeutic target at conditions that cross link the immune system with the skeletal system.