Complementary roles of the orbital prefrontal cortex and the perirhinal-entorhinal cortices in an odor-guided delayed-nonmatching-to-sample task.
Complementary roles of the orbital prefrontal cortex and the perirhinal-entorhinal cortices in an odor-guided delayed-nonmatching-to-sample task.
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DOI：
10.1037//0735-7044.106.5.762
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发表时间：
1992
影响因子：
1.9
通讯作者：
T. Otto;H. Eichenbaum
中科院分区：
文献类型：
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作者：
T. Otto;H. Eichenbaum
持续努力设计气味引导的任务，大鼠的记忆需求，通常与灵长类动物使用的任务相似，导致了一个连续的延迟不匹配的样本（cDNM）任务的发展，这是由嗅觉刺激。结果表明，正常受试者迅速获得cDNM任务，随后的性能恶化的增加，记忆延迟或干扰。此外，不同方面的cDNM的性能被证明是不同的敏感性选择性病变的眶额和海马旁区。眶额皮质病变不成比例地损害了cDNM的收购;延迟性能受损，只有在条件下的干扰水平升高。结合周围和内嗅皮层病变没有影响cDNM收购，但受损的cDNM性能在所有水平的干扰较长的延迟。穹窿病变并没有损害无论是收购的cDNM或随后的性能跨越长时间的延迟和增加的干扰。这种受损和保留能力的模式与猴子在类似区域病变后观察到的相似，并且与前额叶皮层系统优先参与学习一般任务“规则”（如cDNM中固有的非匹配规则）的概念一致，而嗅周和内嗅皮层区域参与特定信息的中期记忆维持。
Continuing efforts toward designing odor-guided tasks for rats that are similar in memory demands to tasks used typically with primates have resulted in the development of a continuous delayed-nonmatching-to-sample (cDNM) task that is guided by olfactory stimuli. The results indicate that normal subjects acquire the cDNM task rapidly and that subsequent performance deteriorates with increases in memory delay or interitem interference. Moreover, different aspects of cDNM performance were shown to be differentially sensitive to selective lesions of the orbitofrontal and parahippocampal areas. Orbitofrontal cortex lesions disproportionately impaired cDNM acquisition; delay performance was impaired only under conditions of elevated levels of interitem interference. Combined perirhinal and entorhinal cortical lesions had no effect on cDNM acquisition but impaired cDNM performance at longer delays across all levels of interference. Fornix lesions did not impair either acquisition of cDNM or subsequent performance across long delays and increased interference. This pattern of impaired and spared capacities is similar to that observed in monkeys after lesions of analogous areas and is consistent with the notion that the prefrontal cortical system contributes preferentially to learning general task "rules" such as the nonmatching rule that is inherent in cDNM, whereas the perirhinal and entorhinal cortical areas are involved in the intermediate-term maintenance of memories for specific information.