Dendritic cell and macrophage heterogeneity in vivo.
Dendritic cell and macrophage heterogeneity in vivo.
复制标题
DOI：
10.1016/j.immuni.2011.09.007
复制
发表时间：
2011-09-23
期刊：
影响因子：
32.4
通讯作者：
Merad M
中科院分区：
文献类型：
--
作者：
Hashimoto D;Miller J;Merad M
巨噬细胞（Macrophage）和树突状细胞（dendritic cell， DC）是存在于所有处于稳定状态的组织中的造血细胞，它们具有对环境采样的能力，但在组织免疫中具有不同的功能。在体内区分巨噬细胞和树突状细胞的最佳方法仍然存在争议。在这一观点中，我们讨论了DC和巨噬细胞谱系起源的最新发现如何帮助确定组织DC和巨噬细胞亚群之间的关键功能差异。我们还强调需要进一步了解组织DC和巨噬细胞谱系的功能异质性，以更好地理解这些细胞在组织稳态和免疫中的复杂作用。
Macrophage and dendritic cell (DC) are hematopoietic cells found in all tissues in the steady state that share the ability to sample the environment but have distinct function in tissue immunity. Controversies remain on the best way to distinguish macrophages from DCs in vivo. In this Perspective, we discuss how recent discoveries in the origin of the DC and macrophage lineage help establish key functional differences between tissue DC and macrophage subsets. We also emphasize the need to further understand the functional heterogeneity of the tissue DC and macrophage lineages to better comprehend the complex role of these cells in tissue homeostasis and immunity.