Resting and exercise electrocardiographic abnormalities associated with sex hormone use in women. The Lipid Research Clinics Program Prevalence Study.
Resting and exercise electrocardiographic abnormalities associated with sex hormone use in women. The Lipid Research Clinics Program Prevalence Study.
复制标题
与女性使用性激素相关的静息和运动心电图异常。
DOI：
10.1093/oxfordjournals.aje.a114226
复制
发表时间：
1986
影响因子：
5
通讯作者：
Heiss,G
中科院分区：
文献类型：
--
作者：
Barrett-Connor,E;Wilcosky,T;Wallace,RB;Heiss,G
根据使用或不使用口服避孕药和外源性雌激素，在1,919名女性参与者中确定静息和运动心电图异常的患病率，这些女性参与者来自脂质研究临床项目的10个定义的北美研究人群。在30-49岁的女性中，在调整年龄、血压、吸烟、饮酒和肥胖后，口服避孕药使用者和非使用者之间静息心电图异常的患病率无显著差异。口服避孕药组运动心电图分级异常发生率高于口服避孕药组（OR = 2.7，p <0.05）。在50岁及50岁以上的女性中，与非雌激素使用者相比，使用雌激素者静息心电图异常Q波明显不足，运动时S-T段异常反应无明显增加。可能的来源的偏见和这些发现的病理生理影响进行了讨论。
Prevalence rates for resting and exercise electrocardiographic abnormalities were determined according to the use or nonuse of oral contraceptives and exogenous estrogens in 1,919 women participants from 10 defined North American study populations of the Lipid Research Clinics Program. Among women 30–49 years of age, no significant differences in the prevalence of resting electrocardiographic abnormalities between oral contraceptive users and nonusers were seen after adjustment for age, blood pressure, cigarette smoking, alcohol, and obesity. Abnormal graded exercise electrocardiograms, however, were more prevalent among the oral contraceptive users (odds ratio = 2.7,p<0.05). Among women 50 years and older, a significant deficit of abnormal Q waves on resting electrocardiogram and nonsignificant excess of abnormal S-T segment responses to exercise were noted in estrogen users compared with nonusers. Possible sources of bias and the pathophysiologic implications of these findings are discussed.