Peroxisome proliferator-activated receptor and vitamin d receptor signaling pathways in cancer cells.
Peroxisome proliferator-activated receptor and vitamin d receptor signaling pathways in cancer cells.
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DOI：
10.3390/cancers5041261
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发表时间：
2013-10-21
期刊：
影响因子：
5.2
通讯作者：
Kitagishi Y
中科院分区：
文献类型：
--
作者：
Matsuda S;Kitagishi Y
过氧化物酶体增殖物激活受体（PPARs）是核激素受体超家族的成员，其通过改变基因表达来响应特异性配体如多不饱和脂肪酸。已经发现了这种受体的三种亚型，每种亚型都在进化以实现不同的生物学功能。与其他核受体一样，PPARs的转录活性不仅受到配体刺激的影响，还受到与其他分子的串扰的影响。例如，PPARs和RXR都是配体激活的转录因子，它们协同调节基因表达。此外，PPARs和维生素D受体（VDR）信号传导途径调节对细胞功能（包括细胞增殖和细胞分化）具有重要意义的多种基因。PPARs和VDR信号通路的相互作用已在其转录因子的分子交叉调节水平上显示。已显示影响PPARs和VDR信号传导途径的多种配体通过介导人类癌症中的肿瘤抑制活性来揭示化学预防潜力。这些化合物的使用可能代表预防癌症的潜在新策略。本文就PPARs和VDR在肿瘤发生发展中的作用作一综述。
Peroxisome proliferator-activated receptors (PPARs) are members of the superfamily of nuclear hormone receptors, which respond to specific ligands such as polyunsaturated fatty acids by altering gene expression. Three subtypes of this receptor have been discovered, each evolving to achieve different biological functions. Like other nuclear receptors, the transcriptional activity of PPARs is affected not only by ligand-stimulation, but also by cross-talk with other molecules. For example, both PPARs and the RXRs are ligand-activated transcription factors that coordinately regulate gene expression. In addition, PPARs and vitamin D receptor (VDR) signaling pathways regulate a multitude of genes that are of importance for cellular functions including cell proliferation and cell differentiation. Interaction of the PPARs and VDR signaling pathways has been shown at the level of molecular cross-regulation of their transcription factor. A variety of ligands influencing the PPARs and VDR signaling pathways have been shown to reveal chemopreventive potential by mediating tumor suppressive activities in human cancers. Use of these compounds may represent a potential novel strategy to prevent cancers. This review summarizes the roles of the PPARs and the VDR in pathogenesis and progression of cancer.