S-Adenosylhomocysteine Analogue of a Fairy Chemical, Imidazole-4-carboxamide, as its Metabolite in Rice and Yeast and Synthetic Investigations of Related Compounds
S-Adenosylhomocysteine Analogue of a Fairy Chemical, Imidazole-4-carboxamide, as its Metabolite in Rice and Yeast and Synthetic Investigations of Related Compounds
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神奇化学物质咪唑-4-甲酰胺的S-腺苷高半胱氨酸类似物，作为其在水稻和酵母中的代谢物以及相关化合物的合成研究
DOI：
10.1021/acs.jnatprod.0c01269
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Toshiyuki Kan
中科院分区：
文献类型：
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作者：
Hitoshi Ouchi ;Takuya Namiki ;Kenji Iwamoto ;Nobuo Matsuzaki ;Makoto Inai ;Mihaya Kotajima ;Jing Wu ;Jae-Hoon Choi ;Yoko Kimura ;Hirofumi Hirai ;Xiaonan Xie ;Hirokazu Kawagishi ;Toshiyuki Kan
在我们对仙女化学物质 (FC) 的研究过程中，我们发现了 S-ICAr-H (8a)，它是大米和酵母（酿酒酵母）中咪唑-4-甲酰胺 (ICA) 的代谢产物。为了确定其绝对构型，开发了8的有效合成方法。该合成策略适用于制备可能具有重要生物学意义的8a类似物，如S-ICAr-M (9)、S-AIAr-H (10) 和S-AIAr-M (11)。
During the course of our investigations of fairy chemicals (FCs), we foundS-ICAr-H (8a), as a metabolite of imidazole-4-carboxamide (ICA) in rice and yeast (Saccharomyces cerevisiae). In order to determine its absolute configuration, an efficient synthetic method of8awas developed. This synthetic strategy was applicable to the preparation of analogues of8athat might be biologically very important, such asS-ICAr-M (9),S-AICAr-H (10), andS-AICAr-M (11).