Diagnostic significance of FDG-PET and argyrophilic nucleolar organizer regions (AgNORs) in oral squamous cell carcinoma
Diagnostic significance of FDG-PET and argyrophilic nucleolar organizer regions (AgNORs) in oral squamous cell carcinoma
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DOI：
10.1016/s1368-8375(03)00151-9
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发表时间：
2004-02-01
期刊：
影响因子：
4.8
通讯作者：
Yonekura, Y
中科院分区：
文献类型：
--
作者：
Nakamura, M;Sano, K;Yonekura, Y
新辅助放化疗在口腔鳞状细胞癌患者的器官和功能保护中发挥了重要作用。为了确定放化疗后是否需要进一步手术，对治疗后残留的肿瘤细胞进行准确的评估是必不可少的。我们研究了局部氟脱氧葡萄糖(FDG)摄取结合从预处理活检标本获得的AgNORs的组织化学表达来评估动脉内放化疗后肿瘤残留的有效性。计算标准化摄取值(SUV：治疗前、治疗前、治疗后、治疗后)，以确定放化疗前后肿瘤对FDG摄取的变化。20例口腔鳞状细胞癌患者中有4例治疗后肿瘤细胞残留。化疗后SUV较高(大于或等于4.0)和AgNORS评分较高(大于或等于5.0)的肿瘤在放化疗后残存肿瘤细胞的发生率显著更高(P=0.001)。结果表明，FDG-PET结合AgNORs评分是确定每个患者在新辅助放化疗后的最佳治疗方案的一个很好的指标。(C)2003爱思唯尔有限公司。保留所有权利。
Neoadjuvant chemoradiotherapy has played an important role in preserving organs and functions in patients with oral squamous cell carcinoma (SCC). To determine whether further operation after chemoradiotherapy is necessary, accurate evaluation of residual tumour cells after treatment is essential. We investigated the usefulness of regional fluorodeoxyglucose (FDG) uptake in combination with histochemical expression of AgNORs obtained from pretreatment biopsy specimens to assess residual tumours after intraarterial chemoradiotherapy. Standardized uptake value (SUV: pretreatment, pre-SUV; post-treatment, post-SUV) was calculated to determine the changes of FDG uptake in the tumour before and after chemoradiotherapy. Four out of 20 patients with oral SCCs showed residual tumour cells after treatment. Tumours with higher post-SUVs (greater than or equal to4.0) and higher AgNORs scores (greater than or equal to5.0) had significantly higher incidences of residual viable tumour cells after chemoradiotherapy (P=0.001). The results suggest that the combination of FDG-PET with AgNORs score is an excellent index for determining the optimal management of each patient following neoadjuvant chemoradiotherapy. (C) 2003 Elsevier Ltd. All rights reserved.