KIAA1199 drives immune suppression to promote colorectal cancer liver metastasis by modulating neutrophil infiltration
KIAA1199 drives immune suppression to promote colorectal cancer liver metastasis by modulating neutrophil infiltration
复制标题
KIAA1199 通过调节中性粒细胞浸润驱动免疫抑制促进结直肠癌肝转移
作者：
Haihong Wang;Biying Zhang;Ruiqi Li;Jiayuan Chen;Guojie Xu;Ying Zhu;Jiao Li;Qing Liang;Qingling Hua;Lanqing Wang;Lu Wen;Min Jin;Jun Fan;Dejun Zhang;Lei Zhao;D;an Yu;Zhenyu Lin;Jinghua Ren;Tao Zhang
转移是癌症死亡的主要原因，并且结肠直肠癌（CRC）经常转移到肝脏。我们前期的研究表明KIAA1199在结直肠癌的侵袭和转移中起重要作用。在本研究中，我们描述了KIAA1199的免疫调节作用，该作用为转移创造了一个允许的环境。
Metastasis is the primary cause of cancer mortality, and colorectal cancer (CRC) frequently metastasizes to the liver. Our previous studies demonstrated the critical role of KIAA1199 in tumor invasion and metastasis in CRC. In the present study, we described an immune regulatory effect of KIAA1199 that creates a permissive environment for metastasis.