Effect of Salt Intake on Serum Glucagon-Like Peptide-1 Levels in Normotensive Salt-Sensitive Subjects
Effect of Salt Intake on Serum Glucagon-Like Peptide-1 Levels in Normotensive Salt-Sensitive Subjects
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DOI：
10.1159/000484152
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发表时间：
2017-10
影响因子：
2.8
通讯作者：
Wen-ling Zheng;C. Chu;Y. Lv;Yang Wang;Jiawen Hu;Qiong Ma;Yu Yan;Yu-Meng Cao;Xi-Long Dang
中科院分区：
文献类型：
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作者：
Wen-ling Zheng;C. Chu;Y. Lv;Yang Wang;Jiawen Hu;Qiong Ma;Yu Yan;Yu-Meng Cao;Xi-Long Dang
背景/目的：过量的食盐是盐敏感型高血压的重要危险因素。胰高血糖素样肽-1(GLP-1)是一种肠内分泌激素，通过利钠和利尿对血压有好处。我们实施了一项随机试验，以验证改变盐摄入量对人类血清GLP-1水平的影响。方法：38名受试者来自中国北部农村社区。所有受试者依次维持3天的基线饮食周期，7天的低盐饮食周期(3.0克/天的氯化钠)，以及7天的高盐饮食周期(18.0克/天的氯化钠)。结果：正常血压盐敏感组(SS)和非盐抵抗组(SR)血清GLP-1水平随低盐饮食向高盐饮食转变而显著升高，随低盐饮食向高盐饮食转变而下降。SS患者血清GLP-1水平与MAP呈显著负相关。不同膳食干预方式下SS患者血清GLP-1水平与24小时尿钠排泄量呈负相关。结论：我们的研究表明，饮食盐摄入量的变化影响正常血压的盐敏感型中国成年人的血清GLP-1水平。
Background/Aims: Excess dietary salt is a critical risk factor of salt-sensitive hypertension. Glucagon-like peptide-1 (GLP-1) , a gut incretin hormone, conferring benefits for blood pressure by natriuresis and diuresis. We implemented a randomized trial to verify the effect of altered salt intake on serum GLP-1 level in human beings. Methods: The 38 subjects were recruited from a rural community of Northern China. All subjects were sequentially maintained a baseline diet period for 3 days, a low-salt diet period for 7 days (3.0g/day of NaCl) , and a high-salt diet period for additional 7 days (18.0g/day of NaCl). Results: Serum GLP-1 level increased significantly with the change from the baseline period to the low-salt diet period and decreased with the change from the low-salt to high-salt diet in normotensive salt-sensitive (SS) but not salt-resistant (SR) individuals. There was a significant inverse correlation between the serum GLP-1 level and the MAP in SS subjects. Inverse correlation between the serum GLP-1 level and 24-h urinary sodium excretion was also found among different dietary interventions in SS subjects. Conclusions: Our study indicates that variations in dietary salt intake affect the serum GLP-1 level in normotensive salt-sensitive Chinese adults.