Role of frontal versus temporal cortex in verbal fluency as revealed by voxel-based lesion symptom mapping
Role of frontal versus temporal cortex in verbal fluency as revealed by voxel-based lesion symptom mapping
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DOI：
10.1017/s1355617706061078
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发表时间：
2006-11-01
影响因子：
2.6
通讯作者：
Dronkers, Nina F.
中科院分区：
文献类型：
--
作者：
Baldo, Juliana V.;Schwartz, Sophie;Dronkers, Nina F.
类别和字母流畅性任务已被用来证明心理和神经分离的语义和语音方面的单词检索。一些先前的神经影像学和病变研究表明，类别流畅性（基于语义的单词检索）主要由颞叶皮层介导，而字母流畅性（基于字母的单词检索）主要由额叶皮层介导。其他研究表明，字母和类别流畅性都是由额叶皮层介导的。我们在一组48名左半球卒中患者中使用基于体素的病变症状映射（VLSM）对这些假设进行了检验。VLSM地图显示，类别和字母流畅性赤字与颞叶和额叶皮质的病变，分别。其他区域，包括顶叶皮层，在这两项任务中都有明显的牵连。因此，我们的研究结果是一致的假设，颞叶皮层subserves词检索语义的约束，而额叶区域是更关键的语音约束的战略词检索。
Category and letter fluency tasks have been used to demonstrate psychological and neurological dissociations between semantic and phonological aspects of word retrieval. Some previous neuroimaging and lesion studies have suggested that category fluency (semantic-based word retrieval) is mediated primarily by temporal cortex, while letter fluency (letter-based word retrieval) is mediated primarily by frontal cortex. Other studies have suggested that both letter and category fluency are mediated by frontal cortex. We tested these hypotheses using voxel-based lesion symptom mapping (VLSM) in a group of 48 left-hemisphere stroke patients. VLSM maps revealed that category and letter fluency deficits correlate with lesions in temporal and frontal cortices, respectively. Other regions, including parietal cortex, were significantly implicated in both tasks. Our findings are therefore consistent with the hypothesis that temporal cortex subserves word retrieval constrained by semantics, whereas frontal regions are more critical for strategic word retrieval constrained by phonology.