Effects of exposure to organic solvents an menstrual cycle length
Effects of exposure to organic solvents an menstrual cycle length
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DOI：
10.1097/00043764-200106000-00012
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发表时间：
2001-06-01
影响因子：
3.2
通讯作者：
Xu, XP
中科院分区：
文献类型：
--
作者：
Cho, SI;Damokosh, AI;Xu, XP
为了调查有机溶剂接触与月经失调之间的关系，我们对中国 1408 名石化工人进行了一项横断面研究。根据工业卫生评价，我们根据是否存在有机溶剂（苯、苯乙烯、甲苯、二甲苯）对车间进行分类。我们使用逻辑回归来估计与暴露相关的月经周期长度延长（月经稀发：上一年平均周期长度>35天）的比值比和95%置信区间。调整混杂因素后，在暴露车间工作每增加一年，月经稀发就会增加 7%（比值比，1.07；95% 置信区间，1.00 至 1.14）。与未接触相比，接触 3 年或以上与月经稀发增加 53% 相关（优势比为 1.53，95% 置信区间为 1.00 至 2.34）。我们得出的结论是，接触有机溶剂与月经稀发频率增加的趋势相关。
To investigate the association between organic solvent exposure and menstrual disturbance, we conducted a cross-sectional study among 1408 petrochemical workers in China. Based on an industrial hygiene evaluation, we classified the workshops according to the presence or absence of organic solvents (benzene, styrene, toluene, or xylene). We used logistic regression to estimate odds ratios and 95% confidence intervals for prolonged menstrual cycle length (oligomenorrhea: average cycle length >35 days during the previous year) associated with the exposure. After adjustment for confounders, each additional year of work in an exposed workshop was associated with a 7% increase in oligomenorrhea (odds ratio, 1.07; 95% confidence interval, 1.00 to 1.14). Compared with no exposure, 3 or more years of exposure was associated with a 53% increase in oligomenorrhea (odds ratio, 1.53, 95% confidence interval, 1.00 to 2.34). We concluded that exposure to organic solvents is associated with a trend toward increased frequency of oligomenorrhea.