Cancer genetics
Cancer genetics
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DOI：
10.1038/35077207
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发表时间：
2001-05-17
期刊：
影响因子：
64.8
通讯作者：
Ponder, BAJ
中科院分区：
文献类型：
--
作者：
Ponder, BAJ
癌症遗传学多年来一直专注于在癌细胞内产生主要影响的突变事件。最近，随着表观遗传事件和细胞相互作用在癌症发展中的重要性的证据，这一焦点已经扩大。共同的遗传变异在确定人群中个体易感性范围方面的作用日益得到认可，并将利用人类基因组计划的信息加以解决。这些新的研究方向将突出癌细胞外的癌症决定因素，提出新的干预目标，并为风险增加群体的预防策略设计提供信息。
Cancer genetics has for many years focused on mutational events that have their primary effect within the cancer cell. Recently that focus has widened, with evidence of the importance of epigenetic events and of cellular interactions in cancer development. The role of common genetic variation in determining the range of individual susceptibility within the population is increasingly recognized, and will be addressed using information from the Human Genome Project. These new research directions will highlight determinants of cancer that lie outside the cancer cell, suggest new targets for intervention, and inform the design of strategies for prevention in groups at increased risk.