Change in Health-Related Quality of Life in Youth with Chronic Hepatitis B Living in North America: A 5-Year Cohort Study.
Change in Health-Related Quality of Life in Youth with Chronic Hepatitis B Living in North America: A 5-Year Cohort Study.
复制标题
居住在北美的患有慢性乙型肝炎的青少年与健康相关的生活质量的变化：一项为期 5 年的队列研究。
DOI：
10.1097/mpg.0000000000003957
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发表时间：
2023
影响因子：
2.9
通讯作者：
HepatitisBResearchNetwork(HBRN)
中科院分区：
文献类型：
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作者：
Schwarzenberg,SarahJane;King,WendyC;Ling,SimonC;Murray,KarenF;Mogul,Douglas;Rosenthal,Philip;Rodriguez-Baez,Norberto;Teckman,Jeffrey;Schwarz,KathleenB;HepatitisBResearchNetwork(HBRN)
背景：在未经治疗的慢性B型肝炎（CH B）青年患者中，更高的肝炎相关病理学与较低的健康相关生活质量（HRQoL）相关。如何HRQoL随时间的变化，在这个population.Methods：儿童从7个肝病中心在北美阳性的肝炎B表面抗原，不采取抗病毒治疗，参加了肝炎B研究网络。一项经过验证的自我报告HRQoL测量，儿童健康问卷儿童报告（CHQ-CF 87），每年由10-17岁的参与者完成，包括人口统计学变量，肝病症状和实验室检查。使用线性混合效应模型评估至少完成两次CHQ-CF 87的参与者在5年内的10个CHQ-CF 87子量表评分。
Background:Greater hepatitis-related symptomology is associated with lower health-related quality-of-life (HRQoL) among untreated youth with chronic hepatitis B (CHB). How HRQoL changes over time in this population is unknown.Methods:Children from 7 hepatology centers in North America positive for hepatitis B surface antigen, not taking anti-viral therapy, were enrolled in the Hepatitis B Research Network. A validated self-report HRQoL measure, the Child Health Questionnaire Child Report (CHQ-CF87), was completed annually by participants 10–17 years, with demographic variables, liver disease symptoms, and laboratory tests. Linear mixed-effects models were used to evaluate the 10 CHQ-CF87 subscale scores over 5 years among participants who completed the CHQ-CF87 at least twice.Results: