Leukaemia incidence after iodine-131 exposure.
Leukaemia incidence after iodine-131 exposure.
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接触碘 131 后白血病发病率。
DOI：
10.1016/0140-6736(92)92421-b
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Tennvall,J
中科院分区：
文献类型：
--
作者：
Hall,P;BoiceJr,JD;Berg,G;Bjelkengren,G;Ericsson,UB;Hallquist,A;Lidberg,M;Lundell,G;Mattsson,A;Tennvall,J
白血病是暴露于电离辐射的最突出的晚期效应之一。我们研究了接触碘-131（131|）诊断原因或治疗甲状腺功能亢进症或甲状腺癌。观察到的白血病数量与基于一般人群发病率数据的预期数量进行比较。骨髓平均吸收剂量估计为14 mGy（范围0.01 - 2.226）。195例白血病发生在暴露后2年以上，标准化发病比（SIR）为1.09（95%置信区间0.94 - 1.25）。慢性淋巴细胞性白血病（CLL）（SIR= 1.08）和非CLL（SIR = 1.09）的风险增加相似，但也不显著。患白血病的风险不因性别、年龄、时间或辐射剂量而异，|除了偶然性之外，没有辐射效应的一个原因包括，如131 I所发生的那样，随着时间的推移，暴露时间延长，风险可能降低。因此，在这一主要为成年人的人群中，可以高度肯定地排除超过25%的白血病风险。这些结果应该是令人放心的病人在医疗实践中暴露于131碘和大多数个人暴露于从切尔诺贝利事故的沉降。
Leukaemia is one of the most prominent late effects of exposure to ionising radiation. We have studied the incidence of leukaemia among 46 988 Swedish patients exposed to iodine-131 (131|) for diagnostic reasons or to treat hyperthyroidism or thyroid cancer.The observed number of leukaemias was compared with that expected based on incidence data from the general population. The mean absorbed dose to the bone marrow was estimated as 14 mGy (range 0·01-2·226). 195 leukaemias occurred more than 2 years after exposure, and the standardised incidence ratio (SIR) was 1·09 (95% confidence interval 0·94-1·25). Similar, but again not significantly, increased risks were seen for chronic lymphocytic leukaemia (CLL) (SIR=1·08), a malignant condition not found to be increased after irradiation, and for non-CLL (SIR = 1·09). The risk of leukaemia did not vary by sex, age, time, or radiation dose from131|.One reason for the absence of a radiation effect, other than chance, includes the possible lowering of risk when exposure is protracted over time as occurs with131I. Excess leukaemia risks of more than 25% could thus be excluded with high assurance in this population of mainly adults. These results should be reassuring to patients exposed to131I in medical practice and to most individuals exposed to the fall-out from the Chernobyl accident.