Electroconvulsive shock and reserpine increase alpha 1-adrenoceptor binding sites but not norepinephrine-stimulated phosphoinositide hydrolysis in rat brain.
Electroconvulsive shock and reserpine increase alpha 1-adrenoceptor binding sites but not norepinephrine-stimulated phosphoinositide hydrolysis in rat brain.
复制标题
电休克和利血平会增加大鼠脑中α1-肾上腺素受体的结合位点，但不会增加去甲肾上腺素刺激的磷酸肌醇水解。
DOI：
10.1016/0014-2999(88)90330-5
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发表时间：
1988
影响因子：
5
通讯作者：
Kellar,KJ
中科院分区：
文献类型：
--
作者：
Blendy,JA;Stockmeier,CA;Kellar,KJ
电休克或利血平反复处理大鼠，可增加大鼠额叶皮层α1肾上腺素受体结合位点的[~ 3 H]哌唑嗪标记密度。相反，去甲肾上腺素刺激的磷酸肌醇水解，这是由α1-肾上腺素受体介导的，没有显着影响的治疗。这些数据表明，电休克和利血平可能只增加或主要增加α1-肾上腺素受体的一种亚型，这种亚型不与磷酸肌醇水解偶联。
Repeated treatment of rats with either electroconvulsive shock or reserpine increased the density of α1-adrenoceptor binding sites labeled by [3H]prazosin in rat frontal cerebral cortex. In contrast, norepinephrine-stimulated phosphoinositide hydrolysis, which is mediated by α1-adrenoceptors, was not significantly affected by either treatment. These data suggest that electroconvulsive shock and reserpine might increase only or predominantly a subtype of α1-adrenoceptor that is not coupled to phosphoinositide hydrolysis.