Does relative melanoma distribution by body site 1960-2004 reflect changes in intermittent exposure and intentional tanning in the Swedish population?
Does relative melanoma distribution by body site 1960-2004 reflect changes in intermittent exposure and intentional tanning in the Swedish population?
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DOI：
10.1684/ejd.2007.0242
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发表时间：
2007-09-01
影响因子：
2.5
通讯作者：
Lindelof, Bernt
中科院分区：
文献类型：
--
作者：
Dal, Henrik;Boldemann, Cecilia;Lindelof, Bernt
在幼年时间歇性暴露于紫外线辐射是恶性黑色素瘤病因学的已知重要因素。我们调查了1960年至2004年瑞典癌症登记处按身体部位分类的黑色素瘤年龄和性别队列的数据，试图了解黑色素瘤身体部位相对分布的主要行为和社会变化。该研究包括来自瑞典癌症登记处的恶性黑色素瘤患者，包括肿瘤身体部位的信息（1960年1月1日至2004年12月31日）。在44，623名患者中，总共诊断出46，337例恶性黑色素瘤。通过每个部位的发病率、每个年龄组和日历期的相对部位分布以及按暴露于阳光的类型划分身体部位（头部（主要是连续的）、躯干（主要是间歇性的）和四肢（混合暴露））来评估趋势。在1960-1964年和2000-2004年期间，男性和女性的上肢（男性885%，女性1216%）、躯干（男性729%，女性759%）和下肢（男性418%，女性289%）的黑色素瘤增长最快。头部肿瘤发病率增长较慢。在整个生命周期中，躯干和下肢的黑色素瘤在< 70岁的患者中占主导地位，而头部的肿瘤在>= 70岁的患者中最常见。在研究期间，躯干肿瘤在所有黑色素瘤中所占比例越来越大，尤其是在女性中。黑色素瘤从头部到躯干的相对转移，大多是间歇性的紫外线照射，与阳光照射方面的行为和社会变化相吻合。这支持了故意暴露于紫外线辐射和恶性黑色素瘤之间的关系的假设。
Intermittent exposure to UV-radiation at an early age is a known important factor the aetiology of malignant melanoma. We surveyed data from the Swedish Cancer Registry for melanoma by body site for age and gender cohorts from 1960 to 2004, in an attempt to discern a reflection of major behavioural and societal changes in the relative distribution of melanoma by body site. The study comprised patients with malignant melanoma from the Swedish Cancer Registry, including information on body site of tumour (January 1, 1960 - December 31, 2004). In total, 46,337 malignant melanomas were diagnosed in 44,623 patients. Trends were assessed by incidence per site, and relative site distribution per age group and calendar period, and dividing body sites by exposure type to the sun: head (mostly continuous), trunk (mostly intermittent), and limbs (mixed exposure). Between calendar periods 1960-1964 and 2000-2004 melanomas increased most rapidly on the upper limbs (men 885%, women 1216%) on the trunk (men 729%, women 759%) and on the lower limbs (men 418%, women 289%) in both genders. The incidence increase of head tumors was slower. Across the life span, melanomas of the trunk and lower limbs dominate among patients < 70 years, whereas tumors of the head are most common among patients >= 70 years. Tumors of the trunk formed an increasing proportion of all melanomas during the period studied, particularly in females. The relative shift of melanomas from the head to the trunk with mostly intermittent UV exposure coincides with behavioral and societal changes with regard to sun exposure. This supports the hypothesis of a relationship between intentional exposure to ultraviolet radiation and malignant melanoma.