Spontaneous formation of germinal centers in autoimmune mice
Spontaneous formation of germinal centers in autoimmune mice
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DOI：
10.1189/jlb.70.4.578
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发表时间：
2001-10
影响因子：
5.5
通讯作者：
I. Luzina;S. Atamas;C. Storrer;Ludmila C. daSilva;G. Kelsoe;J. Papadimitriou;B. Handwerger
中科院分区：
文献类型：
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作者：
I. Luzina;S. Atamas;C. Storrer;Ludmila C. daSilva;G. Kelsoe;J. Papadimitriou;B. Handwerger
自身抗体产生的机制还不清楚。老年中枢（GC）可能是自身免疫性疾病免疫失调的重要部位。在这项研究中，我们记录了几种自发发展自身免疫性I型糖尿病和狼疮样疾病的自身免疫性小鼠品系的脾脏中自发GC形成的存在。相比之下，不发展狼疮的小鼠品系没有表现出GC的自发形成。在所有研究的自身免疫性菌株中，GC在1-2个月大时出现，这与自身抗体的出现密切相关。与有目的免疫后形成的GC一样，自身免疫小鼠中的GC含有B220+、PNA+和GL-7+ B细胞以及FDC-M1+滤泡树突状细胞。此外，通过抗CD 40配体抗体短期治疗，以类似的方式消除了自身免疫中自发形成的GC和免疫引起的GC。这些数据表明，在自身免疫中自发形成的GC与有目的免疫后出现的GC相似。
The mechanisms of autoantibody production are not well understood. Germinal centers (GC) may be important sites of immune disregulation in autoimmune diseases. In this study, we document the presence of spontaneous GC formation in the spleens of several autoimmune mouse strains that spontaneously develop autoimmune Type I diabetes and a lupus‐like disease. In contrast, mouse strains that do not develop lupus did not exhibit spontaneous formation of GC. In all of the autoimmune strains studied, GC were present at 1–2 months of age, a time that closely parallels the appearance of autoantibodies. Like the GC that develop after purposeful immunization, GC in autoimmune mice contained B220+, PNA+, and GL‐7+ B cells, and FDC‐M1+ follicular dendritic cells. In addition, spontaneously formed GC in autoimmunity and those caused by immunization were abrogated in a similar way by a short‐term treatment with anti‐CD40 ligand antibody. These data indicate that spontaneously forming GC in autoimmunity are similar to those appearing after purposeful immunization.