Evaluation of Peripheral Arterial Disease with Nonenhanced Quiescent-Interval Single-Shot MR Angiography
Evaluation of Peripheral Arterial Disease with Nonenhanced Quiescent-Interval Single-Shot MR Angiography
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DOI：
10.1148/radiol.11101336
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发表时间：
2011-07-01
期刊：
影响因子：
19.7
通讯作者：
Edelman, Robert R.
中科院分区：
文献类型：
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作者：
Hodnett, Philip A.;Koktzoglou, Ioannis;Edelman, Robert R.
目的：评估静止期单次激发(QISS)磁共振血管成像的诊断性能，这是一种非增强的二维心电门控单次激发平衡稳态自由进动检查，用于评估症状性慢性下肢缺血。材料和方法：对于这项前瞻性机构审查委员会批准的、符合HIPAA的研究，机构审查委员会免除了对患者知情同意的要求。QISS非增强磁共振血管成像技术在一项双中心试验中进行了评估，该试验涉及53名因可疑或已知慢性外周动脉疾病(PAD)而行下肢MR血管成像的患者，以对比剂增强的MR血管成像作为非侵入性参考标准。对照参考标准评价平扫MR血管成像序列评估狭窄的准确性。计算了每个节段、每个区域和每个肢体的敏感度和特异度，只有当它们与参考标准得出的评估完全一致时，评估才被认为是正确的。使用非结构化二项Logit分析的广义估计方程(GEE)建模来解释每个病例的多个测量的聚集性。QISS磁共振血管成像对确定无意义(
Purpose: To assess the diagnostic performance of quiescent-interval single-shot (QISS) magnetic resonance (MR) angiography, a nonenhanced two-dimensional electrocardiographically gated single-shot balanced steady-state free precession examination for the evaluation of symptomatic chronic lower limb ischemia.Materials and Methods: For this prospective institutional review board-approved, HIPAA-compliant study, the institutional review board waived the requirement for informed patient consent. The QISS nonenhanced MR angiography technique was evaluated in a two-center trial involving 53 patients referred for lower extremity MR angiography for suspected or known chronic peripheral arterial disease (PAD), with contrast material-enhanced MR angiography serving as the non-invasive reference standard. The accuracy of stenosis assessments performed with the nonenhanced MR angiography sequence was evaluated relative to the reference standard. Per-segment, per-region, and per-limb sensitivities and specificities were calculated, and assessments were considered correct only if they were in exact agreement with the reference standard-derived assessments. Generalized estimating equation (GEE) modeling with use of an unstructured binomial logit analysis was used to account for clustering of multiple measurements per case. The sensitivity and specificity of QISS MR angiography for the determination of nonsignificant (