Low or Moderate Dietary Energy Restriction for Long-term Weight Loss: What Works Best?
Low or Moderate Dietary Energy Restriction for Long-term Weight Loss: What Works Best?
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DOI：
10.1038/oby.2009.120
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发表时间：
2009-11-01
期刊：
影响因子：
6.9
通讯作者：
Roberts, Susan B.
中科院分区：
文献类型：
--
作者：
Das, Sai Krupa;Saltzman, Edward;Roberts, Susan B.
理论计算表明，每日少量减少能量摄入可累积导致体重大幅减轻，但缺乏支持这些计算的实验数据。我们在38名超重成人中进行了一项为期1年的低（10%）或中度（30%）能量限制（ER）的随机对照试验研究，饮食中的血糖负荷不同（平均值+/- s.d.，年龄35 ± 6岁; BMI 27.6 ± 1.4 kg/m（2））。提供6个月的食物，并自行选择另外6个月。测量包括体重、静息代谢率（RMR）、使用（H2O）-H-2-O-18评估的ER处方依从性、饱腹感和进食行为变量。10%ER组在12个月内消耗的能量（通过（H2O）-H2-O-18）显著低于处方（18.1 +/- 9.8%ER，P = 0.04），而30%ER组消耗的能量显著更多（23.1 +/- 8.7%ER，P < 0.001）。体重、饱腹感和其他变量的变化在组间没有显著差异。然而，在自主选择饮食（6-12个月）期间，10%ER组的体重变化百分比变异性显著更大（P < 0.001），10%ER组的体重结果较差，这是由较高的基线BMI和较大的去抑制作用预测的（P < 0.0001; adj R-2 = 0.71）。在12个月时，10或30%ER处方组之间的体重减轻没有显著差异，支持低ER建议的有效性。然而，长期体重变化在10%ER上变化更大，该组的体重变化可通过体型和饮食行为预测。这些初步结果表明，低水平的ER对一些但不是所有的个人在体重控制计划的有益影响，并建议可测试的方法优化节食成功的基础上个性化规定的ER水平。
Theoretical calculations suggest that small daily reductions in energy intake can cumulatively lead to substantial weight loss, but experimental data to support these calculations are lacking. We conducted a 1-year randomized controlled pilot study of low (10%) or moderate (30%) energy restriction (ER) with diets differing in glycemic load in 38 overweight adults (mean +/- s.d., age 35 +/- 6 years; BMI 27.6 +/- 1.4 kg/m(2)). Food was provided for 6 months and self-selected for 6 additional months. Measurements included body weight, resting metabolic rate (RMR), adherence to the ER prescription assessed using (H2O)-H-2-O-18, satiety, and eating behavior variables. The 10% ER group consumed significantly less energy (by (H2O)-H-2-O-18) than prescribed over 12 months (18.1 +/- 9.8%ER, P = 0.04), while the 30%ER group consumed significantly more (23.1 +/- 8.7%ER, P < 0.001). Changes in body weight, satiety, and other variables were not significantly different between groups. However, during self-selected eating (6-12 months) variability in % weight change was significantly greater in the 10%ER group (P < 0.001) and poorer weight outcome on 10%ER was predicted by higher baseline BMI and greater disinhibition (P < 0.0001; adj R-2 = 0.71). Weight loss at 12 months was not significantly different between groups prescribed 10 or 30%ER, supporting the efficacy of low ER recommendations. However, long-term weight change was more variable on 10%ER and weight change in this group was predicted by body size and eating behavior. These preliminary results indicate beneficial effects of low-level ER for some but not all individuals in a weight control program, and suggest testable approaches for optimizing dieting success based on individualizing prescribed level of ER.