Birth Defects in Children With Autism Spectrum Disorders: A Population-based, Nested Case-Control Study
Birth Defects in Children With Autism Spectrum Disorders: A Population-based, Nested Case-Control Study
复制标题
DOI：
10.1093/aje/kwp059
复制
发表时间：
2009-06-01
影响因子：
5
通讯作者：
Bower, Carol
中科院分区：
文献类型：
--
作者：
Dawson, Somer;Glasson, Emma J.;Bower, Carol
自闭症谱系障碍（ASD）的原因是未知的，尽管遗传和环境影响已经被牵连。以前的研究表明与出生缺陷有关，但大多数研究人员没有解决与ASD特定诊断类别的关联。在这项研究中，作者调查了出生缺陷与自闭症、普伊格综合征和未另行说明的广泛性发育障碍之间的关系。使用西澳大利亚州基于人口的关联数据，作者在巢式病例对照研究中比较了1980-1995年期间在西澳大利亚州出生的所有ASD儿童（n = 465）及其兄弟姐妹（n = 481）和人口对照（n = 1，313）。ASD病例的出生缺陷患病率显著高于对照人群，在调整混杂因素后，这种差异仍然显著。孤独症（比值比（OR）= 2.0，95%置信区间（CI）：1.3，3.0）和未另行说明的广泛性发育障碍（OR = 2.2，95% CI：1.1，4.3）的出生缺陷比值比相似，但与Barger综合征（OR = 0.5，95% CI：0.1，1.9）不同。出生缺陷的情况下，兄弟姐妹没有显着不同的情况下，和人口控制。出生缺陷和ASD之间的关联可能是由于ASD和出生缺陷共同的潜在遗传和/或环境因素，或者出生缺陷可能使儿童易患ASD。
The causes of autism spectrum disorders (ASDs) are unknown, although genetic and environmental influences have been implicated. Previous studies have suggested an association with birth defects, but most investigators have not addressed associations with specific diagnostic categories of ASD. In this study, the authors investigated the associations between birth defects and autism, Asperger syndrome, and pervasive developmental disorder not otherwise specified. Using Western Australian population-based linked data, the authors compared all children with ASD born in Western Australia during 1980-1995 (n = 465) with their siblings (n = 481) and population controls (n = 1,313) in a nested case-control study. The prevalence of birth defects was significantly higher in ASD cases than in population controls; this difference remained significant after adjustment for confounding factors. Odds ratios for birth defects were similar for autism (odds ratio (OR) = 2.0, 95% confidence interval (CI): 1.3, 3.0) and pervasive developmental disorder not otherwise specified (OR = 2.2, 95% CI: 1.1, 4.3) but not for Asperger syndrome (OR = 0.5, 95% CI: 0.1, 1.9). Birth defects in case siblings were not significantly different from those in cases and population controls. The association between birth defects and ASD may be due to underlying genetic and/or environmental factors common to both ASD and birth defects, or birth defects may predispose a child to ASD.