Longitudinal MRI study of cortical thickness, perfusion, and metabolite levels in major depressive disorder
Longitudinal MRI study of cortical thickness, perfusion, and metabolite levels in major depressive disorder
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DOI：
10.1111/j.1600-0447.2011.01766.x
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发表时间：
2011-12-01
影响因子：
6.7
通讯作者：
Larsson, Elna-Marie
中科院分区：
文献类型：
--
作者：
Jarnum, Hanna;Eskildsen, Simon F.;Larsson, Elna-Marie
目的：确定重度抑郁障碍(MDD)患者在基线磁共振(MR)扫描中是否显示边缘-皮质区域的形态、功能和代谢异常，以及这些变化在缓解期MDD患者的随访中是否正常。方法：采用基于表面的方法测量皮质厚度，三维(3D)伪连续动脉自旋标记(PCASL)灌注测量，和波谱(1H-MRS)测量前扣带回皮质(ACC)，以水为内部参考，调整脑脊液含量。我们检查了23名MDD患者和26名健康对照。MDD患者在纳入时进行基线MRI检查，并在缓解期或6个月随访期后进行随访。结果：主要表现为未缓解组患者的后扣带回皮质较缓解组明显变薄，未缓解组患者额叶和ACC的灌注量显著低于健康对照组，基线时MDD患者的N-乙酰天冬氨酸、肌醇和谷氨酸水平显著低于健康对照组。结论：利用新的MRI技术，我们发现了MDD患者与皮质边缘通路相关的脑区异常。
Objective: To determine whether patients with major depressive disorder (MDD) display morphologic, functional, and metabolic brain abnormalities in limbic-cortical regions at a baseline magnetic resonance (MR) scan and whether these changes are normalized in MDD patients in remission at a follow-up scan.Method: A longitudinal 3.0-Tesla (T) magnetic resonance imaging (MRI) study was carried out with cortical thickness measurements with a surface-based approach, perfusion measurements with three-dimensional (3D) pseudo-continuous arterial spin labeling (pCASL), and spectroscopy (1H-MRS) measurements in the anterior cingulate cortex (ACC) with water as an internal reference adjusted for cerebrospinal fluid content. We examined 23 MDD patients and 26 healthy controls. MDD patients underwent a baseline MRI at inclusion and were invited to a follow-up scan when they were in remission or after a 6-month follow-up period.Results: Major findings were a significantly thinner posterior cingulate cortex in non-remitters than in remitters, a significant decrease in perfusion in the frontal lobes and the ACC in non-remitters compared with healthy controls at baseline and significantly reduced N-acetylaspartate, myo-inositol, and glutamate levels in MDD patients compared with healthy controls at baseline.Conclusion: Using novel MRI techniques, we have found abnormalities in cerebral regions related to cortical-limbic pathways in MDD patients.