Structure Activity Relationship Study of the Cleistriosides and Cleistetrosides for Antibacterial/Anticancer Activity.
Structure Activity Relationship Study of the Cleistriosides and Cleistetrosides for Antibacterial/Anticancer Activity.
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DOI：
10.1021/ml300303g
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发表时间：
2012-12-13
影响因子：
4.2
通讯作者：
O'Doherty, George A.
中科院分区：
文献类型：
--
作者：
Shi, Pei;Silva, Michelle C.;Wang, Hua-Yu Leo;Wu, Bulan;Akhmedov, Novruz G.;Li, Miaosheng;Beuning, Penny J.;O'Doherty, George A.
合成了两种已知的闭花苷和六种已知的闭花苷，并评估了其抗癌和抗菌活性。这项研究首次报道了这些低聚糖天然产物的抗癌活性和抗菌活性。此外，还合成并测试了两种新的非天然闭子苷类似物。发现 10 种寡糖针对枯草芽孢杆菌的生物活性范围为 4 至 >64 µM，针对 NCI-H460 人肺癌上皮细胞的生物活性范围为 7.5 至 90.9 µM。 7 种寡糖针对 NCI 60 个细胞系组也具有类似的活性。特定乙酸基团的酰化程度和位置对闭子苷和闭子苷的抗癌和抗菌活性具有显着影响。
Two known cleistriosides and six known cleistetrosides were synthesized and evaluated for anticancer and antibacterial activity. This study, for the first time, reports anticancer activity and comprehensively the antibacterial activity for these oligosaccharide natural products. In addition, two new unnatural cleistetroside analogues were synthesized and tested. Biological activities for the ten oligosaccharides against B. subtilis were found to range between 4 and >64 µM, and for NCI-H460 human lung cancer epithelial cells between 7.5 and 90.9 µM. Similar activities were found for seven of the oligosaccharides against the NCI panel of 60 cell lines. The degree of acylation and location of the specific acetate groups had significant effects on the anticancer and antibacterial activity of both the cleistriosides and cleistetrosides.
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影响因子：
3.6
作者：
Guo, Haibing;O'Doherty, George A.
通讯作者：
O'Doherty, George A.
影响因子：
3.1
作者：
Cheng, Lijian;Chen, Qi;Du, Yuguo
通讯作者：
Du, Yuguo
影响因子：
3.6
作者：
Shan, Mingde;Xing, Yalan;O'Doherty, George A.
通讯作者：
O'Doherty, George A.
影响因子：
1.8
作者：
TANE, P;AYAFOR, JF;WOODS, N
通讯作者：
WOODS, N
影响因子：
15
作者：
Babu RS;Chen Q;Kang SW;Zhou M;O'Doherty GA
通讯作者：
O'Doherty GA