Antibacterial stilbenes from the tubers of Bletilla striata
Antibacterial stilbenes from the tubers of Bletilla striata
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白芨块茎中的抗菌二苯乙烯类化合物
DOI：
10.1016/j.fitote.2019.104350
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发表时间：
2019-10-01
期刊：
影响因子：
3.4
通讯作者：
Pan, Wei-Dong
中科院分区：
文献类型：
--
作者：
Jiang, Sai;Chen, Chang-Fen;Pan, Wei-Dong
从白头翁的块茎中分离得到3个新的联苯类化合物(bletstrins A-C，1-3)，其中包括2个在脂肪族联苯甲桥上具有羟基取代手性中心的联苯，以及18个已知的二苯乙烯类化合物(4-21)。利用1D/2D核磁共振波谱数据对新化合物的结构进行了鉴定。通过旋光值确定了博莱霉素A和B的绝对构型。化合物13-16为首次从兰科植物中分离得到。大部分化合物对3株革兰氏阳性菌和1株革兰氏阴性菌的抑菌活性进行了评价。化合物4、10、12、14、15、16和18对金黄色葡萄球菌ATCC 6538的最低抑菌浓度(MIC)为6~52mU g/m L。
Three new bibenzyl derivatives (bletstrins A-C, 1 3), including two bibenzyls that have hydroxyl-substituted chiral centers on the aliphatic bibenzyl bridge, along with eighteen known stilbenoids (4-21) were isolated from the tubers of Bletilln striata. The structures of new compounds were elucidated by the use of 1D/2D NMR spectroscopic data. The absolute configurations of bletitrins A and B were determined by optical rotation value. Compounds 13-16 were isolated from the Orchidaceae for the first time. Most of the isolated compounds were evaluated for their antibacterial activities against three gram-positive bacterial strains and one gram-negative bacterial strain. Compounds 4, 10, 12, 14, 15, 16 and 18 showed potent inhibitory activities, with MICs of (6-52 mu g/mL) against S. aureus ATCC 6538.