The formation of citric and α-ketoglutaric acids in the mammalian body
The formation of citric and α-ketoglutaric acids in the mammalian body
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DOI：
10.1042/bj0320113
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发表时间：
1938-01-01
影响因子：
4.1
通讯作者：
Johnson, WA
中科院分区：
文献类型：
--
作者：
Krebs, HA;Salvin, E;Johnson, WA
如果注射柠檬酸，只有一小部分在尿液中出现不变[见Ostberg，1931]，例如在表一中记录的实验中13%。因此，只有一小部分存在于体内的柠檬酸逃脱氧化并进入尿液；因此，有理由认为注射后体内实际形成的柠檬酸和酮戊二酸比我们实验中发现的要多得多。已知丙二酸的排泄是不变的；它不会代谢。对分离的酶系统的研究表明，该酸是一种酶毒物[Quastel&Wooldridge，1929]。丙二酸首先抑制琥珀酸脱氢酶，我们发现相应地琥珀酸在
If citric acid is injected, only a small fraction appears unchanged in the urine [see Ostberg, 1931], for instance 13% in the experiment recorded in Table I. Thus only a small fraction of citric acid present in the body escapes oxidation and is passedinto the urine; it is therefore justifiable to assume that very much more citric ando-ketoglutaric acids are actually formed in the body after the injection than are found in our experiments. Malonic acid is known to be excreted unchanged; it is not metabolized. The work on isolated enzyme systems shows that the acid is anenzyme poison [Quastel & Wooldridge, 1929]. Malonate inhibits in the first place succinic dehydrogenase and we find accordingly a large output of succinic acid after