Behavioral and psychological symptoms associated with dementia subtype and severity
Behavioral and psychological symptoms associated with dementia subtype and severity
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DOI：
10.1017/s1041610209991220
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发表时间：
2010-03-01
影响因子：
7
通讯作者：
Sachdev, Perminder
中科院分区：
文献类型：
--
作者：
Thompson, Claire;Brodaty, Henry;Sachdev, Perminder
背景：越来越多的研究探索阿尔茨海默病(AD)和血管性痴呆(VAD)在行为和心理症状(BPSD)上的差异，但这些差异是不一致的，这种不一致是否可能是由于不同程度痴呆的混淆作用而引起的。方法：用行为问题检查表(BPCL)和修订的记忆与行为问题检查表(RMBPCL)测量BPSD和CDR测量的痴呆严重程度，利用AD(N=377)或VAD(包括多发性脑梗塞和其他血管原因)的档案数据，结果：在控制性别和痴呆严重程度的情况下，AD和VAD患者在BPCL和RMBPCL上的得分没有显著差异。然而，BPSD的严重程度随着痴呆严重程度的增加而增加。结论：在记忆障碍临床人群中，轻中度痴呆患者的BPSD严重程度在最初评估时在AD和VAD中没有差别。然而，在这一组中，BPSD随着痴呆的严重程度而增加。
Background: There is a growing body of research exploring differences in behavioral and psychological symptoms of dementia (BPSD) between Alzheimer's disease (AD) and vascular dementia (VaD), yet these differences are inconsistent and it is uncertain whether this inconsistency might be due to the confounding effect of differing severities of dementia.Methods: BPSD, measured with the Behavior Problems Check List (BPCL) and Revised Memory and Behavior Problems Check List (RMBPCL) and CDR-measured severity of dementia were examined using archival data of individuals with AD (N = 377) or VaD (including multi-infarct and other vascular causes, N = 74) presenting to a Sydney memory disorders clinic over a 20-year period.Results: There was no significant difference in scores for AD and VaD patients on the BPCL or on the RMBPCL when controlling for sex and severity of dementia. However, severity of BPSD increased with increasing severity of dementia.Conclusions: BPSD severity is no different in AD and VaD at the time of initial assessment in a memory disorders clinic population of mild to moderate dementia. However, BPSD increases with severity of dementia in this group.