Association study between vitamin D receptor gene polymorphisms and asthma in the chinese han population: a case-control study
Association study between vitamin D receptor gene polymorphisms and asthma in the chinese han population: a case-control study
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中国汉族人群维生素D受体基因多态性与哮喘的关联研究：病例对照研究
DOI：
10.1186/1471-2350-10-71
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发表时间：
2009-07-21
影响因子：
--
通讯作者：
Liu, Qiji
中科院分区：
文献类型：
--
作者：
Saadi, Ahlem;Gao, Guimin;Liu, Qiji
背景调节免疫系统是维生素D的主要作用之一，其作用是通过维生素D受体(VDR)发挥作用。重要的是，VDR基因的变异在过去一直是易感的，在一些人群中会增加哮喘的风险。VDR等位基因标记的这些效应在中国汉族人群中仍然是推测的。结果在VDR基因的5个SNP上完成了1090名个体(包括567名哮喘患者)的病例对照研究。仅有rs7975232(APAI)标记与哮喘显著相关(P=0.009)。5个VDR基因多态的单倍型分析显示与哮喘显著相关(全局-p值=0.012)。结论虽然本研究中检测的所有SNP都不能证实VDR基因变异与哮喘的易感性，但rs7975232的显著关联为一个关于中国汉族人群的未知报道提供了证据，并可能增加VDR作为哮喘候选基因的易感性。
BackgroundModulation of the immune system is one of the principal roles of Vitamin D, for which the effects are exerted via the vitamin D receptor (VDR). Importantly, variants in the VDR gene have been susceptible in the past to raise the risk of asthma in several populations. These effects of VDR allelic markers remain speculative in the Chinese Han population.ResultsA case-control study of 1090 individuals including 567 asthmatic patients was realized on five SNPs within the VDR gene. Only rs7975232 (ApaI) marker showed a significant association with asthma (P = 0.009). Haplotype analysis of the five VDR polymorphisms showed a significant association with asthma (global-p value = 0.012).ConclusionAlthough the susceptibility of VDR gene variants with asthma could not be confirmed for all SNPs tested in this study, the significant association obtained for rs7975232 provides evidence for a previously unknown report about the Chinese Han population and may raise the susceptibility of VDR to be a candidate gene for asthma.